Results 171 to 180 of about 245,645 (318)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Image1_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG

Purpose: The interaction between inflammatory cells and integrin in the endothelium plays a key role during infiltration. Previous evidence has shown that synthetic C16 peptide selectively binds to integrins αvβ3 and α5β1 and exhibits a neuroprotective ...
Miao-Miao Xu (17906243), Han Qu (4391905), Qiang Li (8118), Xiao-Xiao Fu (11803477), Shu Han (342142), Wen Zhou (49050), Yuan Jiang (296541)   +6 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Corrigendum: Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model

Frontiers in Pharmacology
Wen Zhou, Han Qu, Xiao-Xiao Fu, Miao-Miao Xu, Qiang Li, Yuan Jiang, Shu Han   +6 more
doaj   +1 more source

Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer.

Neutrophils are critical in establishing a tumor-cell-nurturing and immunosuppressive pulmonary "pre-metastatic" niche in breast cancer. The localization and behavior of these neutrophils is, however, not well described.
Declan Whyte (15110992), Seth B Coffelt (16742568), Colin Nixon (589084), Edward W Roberts (21070937), Ximena L Raffo-Iraolagoitia (23606743), Karen Blyth (589090), Frédéric Fercoq (3172713), Ilaria Malanchi (7559081), Lindsey WG Arnott (23606749), Gemma S Cairns (23606731), John BG Mackey (23606737), Anna Kilbey (528167), Leah Brown (17283562), Marco De Donatis (23606734), Alessia Floerchinger (11476963), Judith Secklehner (10666302), Demi Brownlie (11721152), Lynn McGarry (3418214), Robert Wiesheu (16742559), Madeline Harrington (23606746), Victoria Bridgeman (7558190), Sarwah Al-Khalidi (4675939), Leo M Carlin (9071645), Amanda J McFarlane (23606740), Jim C Norman (16074998)   +24 more
core  

Table1_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.DOCX

Purpose: The interaction between inflammatory cells and integrin in the endothelium plays a key role during infiltration. Previous evidence has shown that synthetic C16 peptide selectively binds to integrins αvβ3 and α5β1 and exhibits a neuroprotective ...
Miao-Miao Xu (17906243), Han Qu (4391905), Qiang Li (8118), Xiao-Xiao Fu (11803477), Shu Han (342142), Wen Zhou (49050), Yuan Jiang (296541)   +6 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Image10_Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.JPEG

Purpose: The interaction between inflammatory cells and integrin in the endothelium plays a key role during infiltration. Previous evidence has shown that synthetic C16 peptide selectively binds to integrins αvβ3 and α5β1 and exhibits a neuroprotective ...
Miao-Miao Xu (17906243), Han Qu (4391905), Qiang Li (8118), Xiao-Xiao Fu (11803477), Shu Han (342142), Wen Zhou (49050), Yuan Jiang (296541)   +6 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Immunohistochemical Evaluation of Integrin β6 Expression in Triple-Negative Breast Cancer as a Predictive Biomarker for Therapeutic and Diagnostic Radionuclides. [PDF]

Biomolecules
Tuffaha M, Hananeh W, Bangemann N, Tuffaha A, Starke M.   +4 more
europepmc   +1 more source