Results 131 to 140 of about 350,094 (311)

Investigation of MEMS inertial sensors and aircraft dynamic models in global positioning system integrity monitoring for approaches with vertical guidance

open access: yes, 2009
An Approach with Vertical Guidance (APV) is an instrument approach procedure which provides horizontal and vertical guidance to a pilot on approach to landing in reduced visibility conditions.
Bruggemann, Troy Sterling
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The on-board maritime PNT Module – Concept and preliminary experimental results

open access: yes, 2012
Improvement and Indication of Reliability have been identified as important user needs within the e-Navigation strategy of the International Maritime Organization (IMO).
Ziebold, Ralf   +3 more
core  

”I See You” : Vulnerabitility and Integrity in Relation to Wide-Eye Surveillance

open access: yes, 2022
Smart technologies, political circumstances, economy, and globalization are some of the factors that form a new era of surveillance – a condition Shoshana Zuboff descibes as surveillance capitalism.
Wigorts Yngvesson, Susanne,
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Machine Learning-Based Environment-Aware GNSS Integrity Monitoring for Urban Air Mobility

open access: yesDrones
The increasing deployment of unmanned aerial vehicles (UAVs) in urban air mobility (UAM) necessitates robust Global Navigation Satellite System (GNSS) integrity monitoring that can adapt to the complexities of urban environments.
Oguz Kagan Isik   +2 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

A landscape approach towards ecological integrity of catchments and streams

open access: yes, 2008
Landscape ecology principles were applied to study how in-stream structures as well as terrestrial land cover and land use affect the ecological integrity of streams.
Törnblom, Johan
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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