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Integrons: agents of bacterial evolution
Nature Reviews Microbiology, 2006Integrons are assembly platforms - DNA elements that acquire open reading frames embedded in exogenous gene cassettes and convert them to functional genes by ensuring their correct expression. They were first identified by virtue of their important role in the spread of antibiotic-resistance genes.
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Genetic Variability of Enterobacterial Resistant Integrons
Bulletin of Experimental Biology and Medicine, 2011Sulfamide-resistant (SulR) natural strains of enterobacteria (11.9% of a total of 797 cultures, isolated with enteric microflora of honeybee gut, bee-fermented pollen, and plant issues) were tested for class 1 antibiotic resistance integrons (MRI). Only 5.3% of SulR strains were MRI-positive.
A P, Solomenny +2 more
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Integron and antibiotic resistance
Pathology, 2009Since the advent of antibiotic chemotherapy, the spread of drug resistance genes among clinical isolates of bacteria has become an ever-increasing problem. The increase in drug resistance has been facilitated by the association of antibiotic resistance genes with a variety of mobile genetic elements including plasmids, transposons, integrons and gene ...
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2018
Integrons are genetic recombination platforms that enhance bacterial evolvability by enabling the acquisition and differential expression of new genes. These genes are embedded in mobile elements, named cassettes, which can be stockpiled to form a long array of adaptive functions whose expression is driven by the Pc promoter within the integron ...
José Antonio Escudero +2 more
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Integrons are genetic recombination platforms that enhance bacterial evolvability by enabling the acquisition and differential expression of new genes. These genes are embedded in mobile elements, named cassettes, which can be stockpiled to form a long array of adaptive functions whose expression is driven by the Pc promoter within the integron ...
José Antonio Escudero +2 more
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Shufflons: Multiple Inversion Systems and Integrons
Annual Review of Genetics, 1999▪ Abstract Conservative site-specific recombination functions to create biological diversity in prokaryotes. Simple site-specific recombination systems consist of two recombination sites and a recombinase gene. The plasmid R64 shufflon contains seven recombination sites, which flank and separate four DNA segments.
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Class 1 integrons as invasive species
Current Opinion in Microbiology, 2017Clinical class 1 integrons are a major contributor to the evolution and dissemination of antibiotic resistance. The conserved motifs of these integrons suggest that a single, recent ancestor gave rise to all current variants. They have had a spectacular increase in distribution and abundance over the last 100 years, exhibiting many similarities to ...
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An unusual integron in Treponema denticola
Microbiology, 2004Nick, Coleman +3 more
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