Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Mother-Child Closeness Trajectories in Families of Children With Intellectual Disabilities From a UK Cohort Study. [PDF]
J Intellect Disabil ResTaylor EL +4 more
europepmc +1 more source
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Balancing in Virtual Reality: Motor Learning and Functional Improvement in Down Syndrome. [PDF]
J Intellect Disabil ResArdai E, Vámos T, Papp G, Berencsi A.
europepmc +1 more source
Keeping Pace or Falling Behind? The Depth of Latin American Trade Agreements
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This article examines whether Latin American countries are keeping pace with global trends in trade agreement depth or falling behind. Using 681 agreements (1970–2019), we develop the Depth Index of Trade Agreements (DITA) to weight provisions endogenously through factor analysis based on co‐occurrence patterns.
Raphael Gomes da Silva +2 more
wiley +1 more source
Using Non-Standard Research Methods to Explore the Perspectives of People With Intellectual Disabilities on Sensitive Topics: A Discussion of the Research Paradigm, Data Collection Methods and Data Analysis. [PDF]
J Appl Res Intellect DisabilTuffrey-Wijne I +2 more
europepmc +1 more source
Farmers' Preferences for Gene Editing Crops and Influencing Factors
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Gene editing (GE) is gaining momentum worldwide, but limited data on UK farmers' preferences hinders our understanding of its potential impact amid deregulation debates. Based on a survey of 200 English arable farmers, we employ a Latent Class Analysis and Multinomial Logit regressions to investigate current preferences for GE crops.
Bertolozzi‐Caredio Daniele +1 more
wiley +1 more source
Experiences and Preparedness of Nursing Students and Recent Nurse Graduates Delivering Cardiovascular Health Promotion for People Living With Intellectual Disabilities. [PDF]
J Appl Res Intellect DisabilVan Hulst A +5 more
europepmc +1 more source
AGING MEDICINE, EarlyView.The Setting Standards for Elderly Hospice Care Wards are crucial for meeting urgent elderly patient needs, enhancing hospice care quality, and advancing China's humanized elderly health system. This Standard specifies the configuration requirements for geriatric hospice care wards in terms of ward configuration, staffing models, age‐appropriate ...
Yinan Wu +12 more
wiley +1 more source
Facilitating Research Participation: How Researchers Support People With Communication Support Needs to Decide to Participate. [PDF]
J Appl Res Intellect DisabilLutz DL, Fisher KR.
europepmc +1 more source