Results 131 to 140 of about 1,736,311 (408)

Knowledge, attitudes and practices of psychiatrists in India regarding sudden unexpected death in epilepsy (SUDEP) and seizure-related harm

Epilepsy & Behavior Reports
Sudden unexpected death in Epilepsy (SUDEP) is one of the leading causes of death in people with epilepsy (PWE). Awareness and taking adequate preventive measures are pivotal to reducing SUDEP.
Surobhi Chatterjee, Shivangini Singh, Sujita Kumar Kar, Rohit Shankar   +3 more
doaj   +1 more source

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability

Nature Neuroscience, 2016
To identify candidate genes for intellectual disability, we performed a meta-analysis on 2,637 de novo mutations, identified from the exomes of 2,104 patient–parent trios.
Stefan H. Lelieveld, Margot R. F. Reijnders, R. Pfundt, H. Yntema, E. Kamsteeg, P. D. de Vries, B. D. de Vries, M. Willemsen, T. Kleefstra, Katharina Löhner, M. Vreeburg, S. Stevens, I. van der Burgt, E. Bongers, A. Stegmann, P. Rump, T. Rinne, M. Nelen, J. Veltman, L. Vissers, H. Brunner, C. Gilissen   +21 more
semanticscholar   +1 more source

Aneuploidy and Intellectual Disability [PDF]

, 2012
Aneuploidy is the presence of an abnormal number of chromosomes in cells. The gain or loss of a chromosome in germ cells is the most common cause of chromosomal aneuploidy. Trisomy 21, trisomy 18, and trisomy 13 are characterized by congenital anomalies with intellectual disability (ID) or short lives.
Yasukazu Yamada, Nobuaki Wakamatsu, Reiko Kimura, Toshiyuki Kumagai, Kenichiro Yamada, Seiji Mizuno, Daisuke Fukushi   +6 more
openaire   +3 more sources

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

RE: Impact on psychiatrists in intellectual disability of Court of Protection orders for section 49 (Mental Capacity Act) reports: online survey

BJPsych Bulletin, 2023
Niraj Singh, Asit Biswas
doaj   +1 more source

Living Arrangement Options for People with Intellectual Disabilities: A Scoping Review [PDF]

, 2014
This is one of a pair of reports prepared for the Moving Ahead Project. Its partner policy review, Mapping the National Intellectual Disability Landscape (Linehan et al., 2014), outlines current disability services, practices and policies in Ireland ...
Craig, Sarah, Kerr, Michael, Linehan, Christine, Lynch, Christy, McConkey, Roy, O'Doherty, Siobhain, Staines, Anthony, Tatlow-Golden, Mimi   +7 more
core  

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Psychological status and coping styles of caregivers of individuals with intellectual disability and psychiatric illness.

Journal of Applied Research in Intellectual Disabilities, 2018
BACKGROUND The psychological status of caregivers of individuals with intellectual disability and psychiatric illness (PI) is important for effective management.
Anuja S. Panicker, S. Ramesh
semanticscholar   +1 more source

The concept of sexual exploitation in legislation relating to persons with intellectual disability [PDF]

, 2006
The focus of this paper is on the use of the concept of sexual exploitation in legislation concerning sexual expression by persons with mental impairment, with particular emphasis on persons with intellectual disability.
Graydon, C.M., Hall, G., O'Brien-Malone, A   +2 more
core   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source