Results 71 to 80 of about 1,736,311 (408)

Neuronal mechanisms of mutations in SCN8A causing epilepsy or intellectual disability

Brain : a journal of neurology, 2019
Ion channel mutations can cause distinct neuropsychiatric diseases. We first studied the biophysical and neurophysiological consequences of four mutations in the human Na+ channel gene SCN8A causing either mild (E1483K) or severe epilepsy (R1872W), or ...
Yuanyuan Liu, J. Schubert, L. Sonnenberg, K. Helbig, C. Hoei-Hansen, M. Koko, Maert Rannap, S. Lauxmann, Mahbubul Huq, Michael C. Schneider, K. Johannesen, G. Kurlemann, E. Gardella, F. Becker, Y. Weber, J. Benda, R. Møller, H. Lerche   +17 more
semanticscholar   +1 more source

Mental Illness and Intellectual Disability [PDF]

, 2007
[Excerpt] Both, people with intellectual disability and people with mental illness, suffer from prejudices, negative attitudes, degrading treatment, abuse and discrimination in society. They are often discriminated against by employers, social and health
Inclusion Europe, Mental Health Europe
core   +1 more source

Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evidence of disease activity [NEDA] and its components) between treatment‐naïve relapsing–remitting MS (RRMS ...
Sarmad Al‐Araji, Marcello Moccia, Alessia Bianchi, Charmaine Yam, Weaam Hamed, Suraya Mohamud, Alan J. Thompson, Frederik Barkhof, Ahmed T. Toosy, Olga Ciccarelli   +9 more
wiley   +1 more source

The Situation of People wit Complex Dependency Needs in Europe [PDF]

, 2002
[Excerpt] Since several years, Inclusion Europe and its member societies have put an accent on self-advocacy of persons with intellectual disability. For too long parents and professionals saw persons with intellectual disability only from the angle of ...

core   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Medication Use in Multiple Sclerosis: A Population‐Based Comparison With the General Danish Population

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen, Henrik Horwitz, Ida M. Heerfordt, Elisabeth Framke, Melinda Magyari   +4 more
wiley   +1 more source

IRB challenges in multisite studies: A case report and commentary from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) [version 1; peer review: 3 approved]

HRB Open Research
A shift from single to multi-site health studies enabled a range of research benefits including faster recruitment of larger and more diverse samples; increased statistical power, greater rigour, generalisability, and external reliability; and increased ...
Darren McCausland, Margaret Haigh, Mary McCarron, Philip McCallion   +3 more
doaj   +1 more source

Diagnosis by behavioral observationHome-Videosomnography – A Rigorous Ethnographic Approach to Sleep of Children with Neurodevelopmental Conditions

Frontiers in Psychiatry, 2015
Introduction Advanced video technology is available for sleep-laboratories. However, low-cost equipment for screening in the home setting has not been identified and tested, nor has a methodology for analysis of video recordings been suggested.MethodsWe ...
Osman Sevket Ipsiroglu, Osman Sevket Ipsiroglu, Osman Sevket Ipsiroglu, Yi-Hsuan Amy Hung, Forson eChan, Michelle eRoss, Dorothee eVeer, Sonja eSoo, Gloria eHo, Mai eBerger, Graham eMcAllister, Heinrich eGarn, Heinrich eGarn, Gerhard eKloesch, Adriano Vilela Barbosa, Sylvia eStockler, Sylvia eStockler, William eMcKellin, William eMcKellin, Eric eVatikiotis-Bateson   +19 more
doaj   +1 more source

Attention-deficit hyperactivity disorder in people with intellectual disability: statistical approach to developing a bespoke screening tool

BJPsych Open, 2021
Background Attention-deficit hyperactivity disorder (ADHD) is common among people with intellectual disability. Diagnosing ADHD in this clinically and cognitively complex and diverse group is difficult, given the overlapping psychiatric and behavioural ...
Indermeet Sawhney, Bhathika Perera, Paul Bassett, Asif Zia, Regi T Alexander, Rohit Shankar   +5 more
doaj   +1 more source

Evaluation of the child with global developmental delay and intellectual disability.

Paediatrics & child health, 2018
Global developmental delay (GDD) and intellectual disability (ID) are common concerns in the paediatric setting. Etiologies of both conditions are highly heterogeneous. The American Academy of Pediatrics, the American Academy of Neurology and the British
S. Bélanger, Joannie Caron
semanticscholar   +1 more source