Results 81 to 90 of about 501,307 (362)

SpeechMatch—A novel digital approach to supporting communication for neurodiverse groups

Healthcare Technology Letters
Communication can be a challenge for a significant minority of the population. Those with intellectual disability, autism, or Stroke survivors can encounter significant problems and stigma in their communication abilities leading to worse health and ...
Sarah Lennard, Samuel J. Tromans, Robert Taub, Sarah Mitchell, Rohit Shankar   +4 more
doaj   +1 more source

Acceptability of virtual psychiatric consultations for routine follow-ups post COVID-19 pandemic for people with intellectual disabilities: cross-sectional study

BJPsych Open
Background After the rapid implementation of digital health services during the COVID-19 pandemic, a paucity of research exists about the suitability of remote consulting in people with intellectual disabilities and their carers, particularly for ...
Samuel Tromans, Sarah Rybczynska-Bunt, Sarah Mitchell, Susan Cummins, David Cox, Jennifer Downing, Paul H. Lee, Lucy Teece, Tony Marson, Rohit Shankar   +9 more
doaj   +1 more source

Has teaching about intellectual disability healthcare in Australian medical schools improved? A 20-year comparison of curricula audits

BMC Medical Education, 2020
Background People with intellectual disability (ID) have multiple and complex health needs, more frequent healthcare episodes, and experience poorer health outcomes. Research conducted two decades ago showed that medical professionals were lacking in the
Julian N. Trollor, Claire Eagleson, Beth Ruffell, Jane Tracy, Jennifer J. Torr, Seeta Durvasula, Teresa Iacono, Rachael C. Cvejic, Nicholas Lennox   +8 more
doaj   +1 more source

Bioinspired Design of a Wet‐Adhesive Cornea Glue Based on Recombinant Human Protein Networks

Advanced Functional Materials, EarlyView.
Natures protein‐based high performance materials e.g. elastin, silk and muscle proteins have been mimicked by a new protein‐hybrid material based on redesigned human partial sequences only, showing high wet‐adhesiveness and elasticity for biomedical applications.
Anna Resch, Matthias C. Huber, Alexander Resch, Andreas Schreiber, Thabo Lapp, Jan Dittrich, Frederic Eisen, Austin Julian Michalec, Viktoria Planz, Adrianna Kolberg, Mathaeus Tschaikowsky, Daniel Böhringer, Maike Windbergs, Thomas Reinhard, Bernd Rolauffs, Bizan N. Balzer, Günther Schlunck, Stefan M. Schiller   +17 more
wiley   +1 more source

Epigenetic Etiology of Intellectual Disability [PDF]

The Journal of Neuroscience, 2017
Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other epigenetic regulators have been genetically associated with ID disorders (IDDs).
Iwase, S., Berube, N.G., Zhou, Z., Nadif Kasri, N., Nadif Kasri, N., Battaglioli, E., Scandaglia, M., Barco, A.   +7 more
openaire   +6 more sources

Mussel‐Inspired Molecular Strategies for Fabricating Functional Materials With Underwater Adhesion and Self‐Healing Properties

Advanced Materials, EarlyView.
This review systematically examines the nanomechanical mechanisms of mussel‐inspired molecular interactions, primarily investigated by direct force measurement techniques such as surface forces apparatus and atomic force microscopy. The macroscopic adhesive and self‐healing performances of mussel‐inspired functional materials, including coacervates ...
Pan Huang, Hongjian Zhang, Hongbo Zeng
wiley   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source