Results 31 to 40 of about 10,364,935 (290)
Imputation of missing information in worldwide patent data
Data in Brief, 2021 We present a general method for imputing missing information in the Worldwide Patent Statistical Database (PATSTAT) and make the resulting datasets publicly available. The PATSTAT database is the de facto standard for academic research using patent data.
Gaétan de Rassenfosse, Florian Seliger
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Management System Engineering, 2023 This study explores and explains how duality enables disruptive innovation to encroach on the market and redefine its boundaries under constraints of consumer preferences, purchasing power, technological performance, and complementary technologies.
Yongchao Zeng +3 more
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Re-thinking the role of intellectual property [PDF]
, 2013 The context in which intellectual property (IP) operates in the contemporary world is vastly different from the one in which IP was born. The new context has changed the position of IP both in the economy and in society.
Francis Gurry
core
Research on Chinese patent classification based on structured features
Scientific ReportsThe three dimensions of Function, Structure, and Purpose are fundamental to patent classification and play a decisive role in improving the accuracy of patent information categorization. By providing targeted abstracts for each of these three dimensions,
Ran Li, Wangke Yu, Shuhua Wang
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A Battery Electric Vehicle Transportation Network Design Model with Bounded Rational Travelers
Journal of Advanced Transportation, 2023 With governments worldwide emphasizing environmental protection and the global focus on carbon reduction, the battery electric vehicle (BEV) industry has developed rapidly. An urban transportation network with BEVs as the main form of transportation will
Xu Xin +5 more
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Heliyon, 2023 The implementation of occupational health and safety management in the supply chain by core enterprises is a significant step towards improving the working conditions of their suppliers.
Qiaomei Zhou +3 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source