Results 41 to 50 of about 51,412 (307)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Desenvolvimento sustentável de setores emergentes quanto a propriedade intelectual diante da globalização econômica e da Internet das Coisas

RAE: Revista de Administração de Empresas
Este artigo propõe um método para aprimorar a produção agrícola sob a perspectiva da produção agrícola inteligente para melhorar a eficiência dessa área em indústrias emergentes em propriedade intelectual.
Xiaolong Liang, Mengyao Chen, Zichen Liu, Tiantian Qu   +3 more
doaj   +1 more source

以不正方法取得營業秘密之未遂犯 ──美國法著手犯的借鏡 Criminal Attempt of Improperly Acquiring Trade Secrets Under the Trade Secret Act ―A Lesson from the Concept of “Attempt” Under the United States Criminal Law

交大法學評論, 2023
本文意在參酌美國聯邦《經濟間諜法》（Economic Espionage Act, EEA）與《模範刑法法典》（Model Penal Code, MPC）第5.01條之著手犯之法制，來思考我國營業秘密法犯罪行為中的未遂犯意涵。本文指出意圖竊取他人營業秘密、並進而著手以不正方法取得他人之資訊者，只要該行為人以為到其所取得的資訊為營業秘密，其即應負未遂犯之責。該認識之成立可基於被害單位客觀上有執行營業秘密合理保密措施。 This article provides the definition of ...
陳秉訓 Ping-Hsun Chen
doaj  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

論涉及專利連結之專利侵權訴訟 與其訴訟標的價額之計算 Patent-Linkage-Related Patent Infringement Civil Litigation and Valuation of a Cause of Action

交大法學評論, 2022
2019 年起藥事法實施專利連結制度，於學名藥廠申請學名藥藥品許可證之過程中，提供原藥廠提早解決專利權侵害爭議之機制。本文意在藉由過去智財法院涉及藥品專利的民事訴訟裁定，共四件案例，以提出在涉及專利連結之專利侵權訴訟中訴訟標的價額之計算方法。案例1與案例4皆屬原藥廠與學名藥廠間的訴訟，但涉及不同原廠藥。案例2、案例3、與案例4涉及相同原廠藥，但三個案件的被告分別為藥局、藥品經銷商、與學名藥廠。最後，本文建議在涉及專利連結之專利民事訴訟中，原告排除侵害請求權之訴訟標的價額之計算公式為 ...
陳秉訓 Ping-Hsun Chen
doaj  

On Competition and the Strategic Management of Intellectual Property in Oligopoly [PDF]

Journal of Economics & Management Strategy, 2009
An innovative firm with private information about its indivisible process innovation chooses strategically whether to apply for a patent with probabilistic validity or rely on secrecy. By doing so, the firm manages its rivals’ beliefs about the size of the innovation, and affects the incentives in the product market.
openaire   +8 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Management of intellectual property in the football clubs: technology strategy and tactics (for example, municipal institution of FC «Rubin») [PDF]

Aktualʹnye Problemy Èkonomiki i Prava, 2014
Objective to form the conceptual framework in the field of intellectual property management in football clubs to develop directions of intellectual property management development in FC quotRubinquot Kazan.
Guzel I. Gumerova, Elmira Sh. Shaimieva
doaj   +1 more source