Results 41 to 50 of about 587,368 (307)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Economic Impact of Intellectual Property Management: Towards Model of Intellectual Property Management

Proceedings of the 17th International Joint Conference on e-Business and Telecommunications, 2020
Subject literature indicates the International Business Machines (IBM) as the uninterrupted leader in the number of patents obtained from United States Patents and Trademarks Office (USPTO), out of all enterprises and industries for over 25 years. Since 1998, the IBM has conducted an internal business segment called Intellectual Property Management ...
openaire   +2 more sources

Developing the Curriculum for Collaborative Intellectual Property Education [PDF]

, 2006
Intellectual property education, i.e. how intellectual property should be taught or more importantly how intellectual property is learnt, is a recent addition to the academic 'intellectual property' agenda.
Soetendorp, Ruth
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

IP Basics: Managing Intellectual Property [PDF]

, 2015
This provides an overview of the IP management process, including the key decisions to be made in the effort to make the most of intellectual ...
Field, Thomas G., Jr.
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Desenvolvimento sustentável de setores emergentes quanto a propriedade intelectual diante da globalização econômica e da Internet das Coisas

RAE: Revista de Administração de Empresas
Este artigo propõe um método para aprimorar a produção agrícola sob a perspectiva da produção agrícola inteligente para melhorar a eficiência dessa área em indústrias emergentes em propriedade intelectual.
Xiaolong Liang, Mengyao Chen, Zichen Liu, Tiantian Qu   +3 more
doaj   +1 more source

以不正方法取得營業秘密之未遂犯 ──美國法著手犯的借鏡 Criminal Attempt of Improperly Acquiring Trade Secrets Under the Trade Secret Act ―A Lesson from the Concept of “Attempt” Under the United States Criminal Law

交大法學評論, 2023
本文意在參酌美國聯邦《經濟間諜法》（Economic Espionage Act, EEA）與《模範刑法法典》（Model Penal Code, MPC）第5.01條之著手犯之法制，來思考我國營業秘密法犯罪行為中的未遂犯意涵。本文指出意圖竊取他人營業秘密、並進而著手以不正方法取得他人之資訊者，只要該行為人以為到其所取得的資訊為營業秘密，其即應負未遂犯之責。該認識之成立可基於被害單位客觀上有執行營業秘密合理保密措施。 This article provides the definition of ...
陳秉訓 Ping-Hsun Chen
doaj  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source