Results 31 to 40 of about 26,229 (254)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Strategies for the source protection of data assets on processing techniques for intelligent manufacturing in traditional Chinese medicine

Frontiers in Public Health
The digital transformation of traditional Chinese medicine (TCM) processing techniques currently faces a critical industry bottleneck: the lack of rights protection for source knowledge contributors, which results in an insufficient supply of high ...
Siyue Chen, Jinlian Zhang
doaj   +1 more source

NATURE OF INTELLECTUAL PROPERTY INSURANCE AND ITS ROLE IN MODERN ECONOMY

Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015
Article is devoted to theoretical analysis of nature and mechanism of intellectual property insurance. Types of intellectual property relations and its role in public reproduction are investigated.
V. Bazylevych, V. Virchenko
doaj   +1 more source

Terrorism and Intellectual Property Rights

AMA Journal of Ethics, 2004
A bioethicist argues that the government has the right to restrict or override intellectual property rights in response to a national emergency only when specific criteria are met. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The strength of intellectual property protection, corporate financing constraints, and corporate governance efficiency: Mechanisms and heterogeneity analysis

International Review of Economics & Finance
This paper aims to conduct an in-depth investigation into the complex relationship among the strength of intellectual property protection, corporate financing constraints, and corporate governance efficiency. To this end, it selects Chinese non-financial
Dong Wang, Bibo Ding
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Health and intellectual property rights

Ceylon Medical Journal, 2014
مجلة سيلان الطبية (CMJ) هي مجلة خاضعة لمراجعة الأقران ومفتوحة الوصول تنشرها الجمعية الطبية السريلانكية كل ثلاثة أشهر في الأسبوع الأخير من مارس ويونيو وسبتمبر وديسمبر من كل عام. تتمثل مهمة CMJ في تعزيز علم وفن الطب وتحسين الصحة العامة. تنشر المجلة أوراقًا وتعليقات أصلية ذات صلة بالطب والعلوم المرتبطة به.
openaire   +4 more sources