Results 51 to 60 of about 26,229 (254)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The Impact of Intellectual Property Rights Enhancement on Corporate Resilience during Economic Crises

Journal of Intellectual Property
This study analyzed the impact of intellectual property rights enhancement on changes in corporate sales and employment and business resilience during economic crises based on ”The Survey of Business Activities” data from 2018 to 2022. The results of the
Minho Kim, Sang-Ok Choi
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

The construction of ‘invalidation of intellectual property rights’ as a way to protect the right: a tragic experience of catharsis

Теорія і практика інтелектуальної власності
When considering disputes in the field of intellectual property, a method of protecting subjective rights is often used, such as declaring a legal fact that establishes an intellectual property right invalid.
Serhii Vavzhenchuk
doaj   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

THE CORRELATION OF «INTELLECTUAL PROPERTY» AND «INTELLECTUAL RIGHTS» CONCEPTS IN THE LEGISLATION FRAMEWORK OF THE RUSSIAN FEDERATION

Гуманитарные и юридические исследования, 2021
The article analyzes the correlation of «intellectual property» and «intellectual property rights» concepts. The findings reveal that there are various definitions of «intellectual property» and «intellectual property rights» concepts in the literature ...
Yu. N. Slepenok, I. M. Vil'gonenko, A. D. Anuchkina   +2 more
doaj  

Intellectual Property Rights: Infringement and Calculation of Damages

Católica Law Review, 2017
A Comment on the Judgment of the Court of Justice of the European Union (Fifth Chamber) Stowarzyszenie ‘Olawska Telewizja Kablowa’ v Stowarzyszenie Filmowców Polskich, 25 January 2017 (Case C-367/15)
openaire   +4 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A Study on the Sublicensing System of Intellectual Property Rights

Journal of Intellectual Property
Sublicensing in the context of intellectual property rights refers to a license granted by a licensee to a third party under the authority granted to the licensee.
Sucheol Kim
doaj   +1 more source

The Value of Intellectual Property Rights to Firms. [PDF]

, 2007
Economists view intellectual property rights (IPRs) as policy tools for encouraging innovation. There are many types of IPRs and of institutions concerned with their administration. We begin by outlining how these complex and varied rights are supposed to work and how they interact with other characteristics of firms and markets.
Christine Greenhalgh, Mark Rogers
openaire   +3 more sources