Results 31 to 40 of about 4,110 (253)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Latin American Philosophers: Some Recent Challenges to Their Intellectual Character

Informal Logic, 2016
For Latin American philosophers, the quality of their own philosophy is a recurrent issue. Why hasn’t it produced any internationally recognized figure, tradition, or movement? Why is it mostly unknown inside and outside Latin America? Although skeptical
Susana Nuccetelli
doaj   +3 more sources

AI Algorithms as (un)virtuous knowers

Discover Artificial Intelligence
The paper explores how well AI algorithms can fare with regards to intellectual virtues compared to humans. The paper argues that if intellectual virtues are understood functionally as displaying behavior similar to human virtuous behavior, AI algorithms
Hans Van Eyghen
doaj   +1 more source

OLD HABITS DIE HARD: THE ROYAL SOCIETY, THEOPHILUS GALE AND THE INTELLECTUAL VIRTUES [PDF]

Societate şi Politică, 2012
There were several English attempts to rethink ideas about cognitionin the wake of the new attention and status given to natural philosophy in theseventeenth century.
Daniel ANDERSSON
doaj  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Review of the 23rd International Conference on Ethics Across the Curriculum

Філософія освіти, 2023
The review presents the key ideas discussed at the 23rd International Conference on Ethical Education in Curriculum “The Ethics of Engagement” (“The Ethics of Engagement”), held from October 6 to 8, 2022 at the University of Mississippi, Oxford ...
Юлія Кравченко
doaj   +1 more source

Design Strategies and Emerging Applications of High‐Performance Flexible Piezoresistive Pressure Sensors

Advanced Functional Materials, EarlyView.
Flexible piezoresistive pressure sensors underpin wearable and soft electronics. This review links sensing physics, including contact resistance modulation, quantum tunneling and percolation, to unified materials/structure design. We highlight composite and graded architectures, interfacial/porous engineering, and microstructured 3D conductive networks
Feng Luo, Artur Ciesielski, Paolo Samorì   +2 more
wiley   +1 more source

Does the Excellent Enactment of Highest Strengths Reveal Virtues?

Frontiers in Psychology, 2020
Two studies examined the assumption that character strengths enable virtues and facilitate the good life. Study 1 validated a “layperson’s excellent enactment of highest strengths paradigm”.
Fiorina Giuliani, Willibald Ruch, Fabian Gander   +2 more
doaj   +1 more source

The Ni,Cd Heteroatoms‐Initiated Synergistic Tuning of Electron Configuration in Fe2VO4 Nanosheets Electrocatalysts to Profoundly Stabilize Alkaline Seawater Electrolysis

Advanced Functional Materials, EarlyView.
A Ni,Cd‐codoped Fe2VO4/NF bifunctional electrocatalyst is rationally designed for efficient seawater electrolysis. Synergistic effect modulates electron configuration, optimizes intermediates adsorption, stabilizes high‐valence Fe/V sites, and repels chloride ions to suppress corrosion and side reactions, thus contributing to performance improvement of
Weiguo Huang, Bin Fang, Tao Meng, Xiaodong Chen, Ya Chen, Xin Gao, Fei Liang, Hongchao Sun, Jiangmin Zou, Chao Yuan, Yuanyuan Shao, Peiyi Ji, Yangang Wang, Lifeng Cui, Guoxiu Wang, Duu‐Jong Lee   +15 more
wiley   +1 more source