Results 61 to 70 of about 32,107 (312)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Postmodernism and the humanities: The case of historiography [PDF]

open access: yesGlasnik Etnografskog Instituta SANU, 2013
Postmodernism, as a specific ideal orientation, typical of the last three decades of 20th century, reached historiography with certain delay. Particularly with the thesis of impossibility to know the past, postmodernism strongly influenced ...
Nikolić Kosta
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The effective intellectual–cultural currents in women’s rights in Iran after Islamic revolution [PDF]

open access: yesزن در فرهنگ و هنر, 2014
This study examines votes, ideologies and goals of Iran’s cultural-intellectual currents after the Islamic Revolution in order to describe their scale and type impacts on women rights in Iran.
Shahla Bagheri, Nahid Salimi
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Contextualism and Intellectualism [PDF]

open access: yes, 2010
This is a preprint of an article published in Philosophical Perspectives, Volume 24, Issue 1, pages 383-405, December 2010. The definitive version is available at www3.interscience.wiley.com doi: 10.1111/j.1520-8583.2010.00197.xThe main goal of this ...
McGrath, Matthew
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Socratic Appetites as Plotinian Reflectors: A New Interpretation of Plotinus’s Socratic Intellectualism

open access: yesRevista de Filosofia Antiga, 2020
Enneads I: 8.14 poses significant problems for scholars working in the Plotinian secondary literature. In that passage, Plotinus gives the impression that the body and not the soul is causally responsible for vice.
Brian Lightbody
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

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