Results 91 to 100 of about 461 (173)

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Tea tree recognition based on multi-source satellite data across Southeast China. [PDF]

Front Plant Sci
Cong N, Zhao R, Qiu Y, Zhao C.
europepmc   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Spatio-temporal patterns and driving mechanisms of ecosystem services in mountainous regions: A multi-scale analysis of the Yanshan-Taihang mountain area. [PDF]

Sci Rep
Che J, Zhu X, Niu X.
europepmc   +1 more source

A Deep Nonlinear Subspace Modeling and Reconstruction for Diffusion‐Weighted Imaging Using Denoising Auto‐Encoder

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To present a novel, nonlinear subspace modeling and joint k–q‐space reconstruction technique for high‐resolution, multi‐band, multi‐shell diffusion‐weighted imaging (DWI). Methods High b‐value (> 1000 s/mm2), high resolution DWI has the drawback of generally low signal‐to‐noise ratios (SNRs).
Julius Glaser, Zhengguo Tan, Annika Hofmann, Frederik Bernd Laun, Florian Knoll   +4 more
wiley   +1 more source

Peptide-protein docking: from physics-based models to generative intelligence.

Chem Commun (Camb)
Ling K, Li S, Zhang Z, Shin WH, Kihara D.   +4 more
europepmc   +1 more source

From genotype to phenotype: decoding mutations in blasts by holo-tomographic flow cytometry. [PDF]

Light Sci Appl
Pirone D, Di Natale C, Di Summa M, Mosca N, Giugliano G, Schiavo M, Florio D, Marasco D, Maffettone PL, Miccio L, Memmolo P, Ferraro P.   +11 more
europepmc   +1 more source

Artificial Intelligence Driven Innovation: Advancing Mesenchymal Stem Cell Therapies and Intelligent Biomaterials for Regenerative Medicine. [PDF]

Bioengineering (Basel)
Huang M, Dissanayaka WL, Yiu CKY.
europepmc   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source