Results 101 to 110 of about 1,215,136 (146)

Optical Stimulation and Monitoring of the Peripheral Nervous System: Perspectives and Challenges Toward Clinical Translation

Laser &Photonics Reviews, EarlyView.
Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo, Sarassunta Ucci, Anna Aliberti, Patrizio Vaiano, Alessia La Rocca, Francesca Angelone, Silvia Pascarella, Pellegrino Lippiello, Maria Concetta Miniaci, Giuseppe Prisco, Michela Russo, Francesco Amato, Deyanira Contartese, Milena Fini, Gianluca Giavaresi, Lucia Martini, Francesco Rosa, Cosimo Gentile, Emanuele Gruppioni, Armando Ricciardi, Andrea Cusano   +20 more
wiley   +1 more source

First and Second Law Analysis Approach for the Study of Internal Combustion Engine Waste Heat Recovery with Organic Rankine Cycles (ORC)

, 2016
LION, SIMONE, TACCANI, RODOLFO, Vlaskos, Ioannis, Rouaud, Cedric   +3 more
core  

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Climate‐Resilient Agri‐Food Systems (CRAFS): A Review of Approaches and Outcomes of Agri‐Food Systems

Sustainable Development, EarlyView.
ABSTRACT Climate change is increasingly destabilizing agri‐food systems globally, with complex disruptions extending across production, distribution, and consumption. In response, climate‐resilient agri‐food system (CRAFS) approaches have gained prominence as a means to sustain food security under escalating climatic stressors.
M Manjurul Islam, Evan D. G. Fraser
wiley   +1 more source

Artificial Intelligence for Blue Transformation: A Review of Predictive Modeling and Decision Support Systems in Sustainable Aquaculture

Sustainable Development, EarlyView.
ABSTRACT The FAO's “blue transformation” roadmap necessitates a fundamental shift towards precision aquaculture to meet global food security targets while minimizing environmental footprints. This review provides a comprehensive overview of how artificial intelligence (AI) and decision support systems (DSS) serve as pivotal enablers for the “better ...
Mustafa Öz, Enes Üstüner
wiley   +1 more source

Exploring the Sustainability Landscape of Nature‐Based Solutions in Food Systems

Sustainable Development, EarlyView.
ABSTRACT Nature‐based solutions (NbS) offer a pathway toward more resilient food systems. Although previous studies analysed various sustainability benefits of integrating NbS within food systems, the field remains fragmented, with a significant gap in understanding development patterns, emerging research trends at the intersection of NbS, food systems,
Elaheh Jalilzadehazhari
wiley   +1 more source