Results 121 to 130 of about 456 (171)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Unifying the odyssey: artificial intelligence for rare disease diagnosis and therapy. [PDF]

Health Technol (Berl)
Ho ML, Zitnik M, Azachi R, Basu S, Rajpurkar P, Sidlow R.   +5 more
europepmc   +1 more source

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin, Yuhan Zhang, Yuantai Zhu, Zhiyuan Zhang, Chaoji Shi   +4 more
wiley   +1 more source

Analysis of Biological Images and Quantitative Monitoring Using Deep Learning and Computer Vision. [PDF]

J Imaging
Gálvez-Salido A, Robles F, Gonçalves RJ, Herrán R, Ruiz Rejón C, Navajas-Pérez R.   +5 more
europepmc   +1 more source

ABSTRACTS

Precision Radiation Oncology, EarlyView.
wiley   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

A spinal network of proprioceptive reflexes can produce a variety of bipedal gaits. [PDF]

Commun Biol
Bunz EK, Haeufle DFB, Schmitt S, Geijtenbeek T.   +3 more
europepmc   +1 more source

Smart Face Masks as Wearable Respiratory Sensors: A Review of Sensor Technologies, Materials, and Future Directions

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
This review highlights recent advances in smart face masks that actively monitor breathing. By integrating humidity, gas, temperature, pressure, strain, and triboelectric sensors, these masks track key respiratory parameters in real time. The article summarizes sensor mechanisms, compares performance across studies, and discusses challenges and future ...
Negin Faramarzi, Naseeh Backer Kannanthodi, Alice Nicole Casling, Babar Ali, Samira Lakouraj Mansouri, Alessandro Giuseppe D'aloia, Hossein Cheraghi Bidsorkhi, Maria Sabrina Sarto   +7 more
wiley   +1 more source

An evaluation of machine learning for soil analysis in internet of things-enabled smart farming. [PDF]

Sci Rep
Chaudhary P, Gulia P, Gill NS, Alduaiji N, Shukla PK, Vishnoi S.   +5 more
europepmc   +1 more source