Results 91 to 100 of about 10,696 (210)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Controlled Peptide Capture and Release in 3D‐Printed Multimaterial Microstructures

Advanced Science, EarlyView.
Two‐photon laser printing of 3D microstructures using a peptide‐containing ink is shown. The microstructures allow for controlled capture and release of target peptides through coiled‐coil interaction with the printed peptide inside the material. Based on these properties, orthogonal capture and stimuli‐mediated release possibilities inside printed ...
Niklas Schwegler, Thomas Heim, Philipp Mainik, Eva Blasco, Franziska Thomas   +4 more
wiley   +1 more source

A High‐Resolution Self‐Powered Angular Displacement Sensor Based on Triboelectric Nanogenerator With Time‐Grating

Advanced Science, EarlyView.
A self‐powered phase‐encoding sensing paradigm enables direct motion‐to‐time information conversion, providing a compact and autonomous strategy for high resolution angular displacement measurement. ABSTRACT In modern manufacturing and engineering, angular displacement sensors are crucial for motion control and feedback systems in Electromechanical ...
Shuxian Wang, Donghang An, Shiyou Liu, Zhiyi Wu   +3 more
wiley   +1 more source

Advancing safety through connected and autonomous vehicles: a meta-analysis of market penetration and safety improvement rates from 2015 to 2024

European Transport Research Review
The field of Connected and Autonomous Vehicles (CAVs) promises to improve road safety through advanced communication technologies and data sharing.
Amirhossein Taheri, Jing Yang, Steffen Müller, Dimitris Milakis, Mohammed Quddus   +4 more
doaj   +1 more source

Bio‐Inspired Bidirectional Winding Origami With Programmable Modular Reconfigurability and Scalability

Advanced Science, EarlyView.
A bio‐inspired bidirectional‐winding origami platform enables scalable and programmable deployable structures. Double axial folding inspired by earwig hindwings and Flasher‐based hybridization create modular multilayer architectures with diverse attainable winding angles under fixed boundary conditions.
Wenyao Zhang, Chunlong Wang, Mingli Liu, Chuang Shi, Hongwei Guo, Rongqiang Liu   +5 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots

Advanced Science, EarlyView.
We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou, Yitong Li, Junda Huang, Ian Zhang, Haoran Liu, Boyuan Liang, Yiyuan Zhang, Xiaohui Xiao, Qiguang He   +8 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source