Results 21 to 30 of about 1,371,293 (266)

Exploring the Impact of a Railway Corridor on Intermodal Service Networks and Industrial Location: A Land-Use Transport Interaction Modeling Approach

Journal of Advanced Transportation
Given the intricate interactions among the economy, land use, and transportation, it is important to assess the multifaceted impacts of the freight corridor on these systems. This study introduces a land-use transport interaction (LUTI) modeling approach
Zongbao Wang, Ming Zhong, Xiaofeng Pan, Linfeng Li   +3 more
doaj   +1 more source

Structural analysis of driver fatigue behavior: A systematic review

Transportation Research Interdisciplinary Perspectives, 2023
Fatigue is always accompany with the driving task, which have been extensively investigated for driver monitoring and traffic safety. While many scholars dedicate to the study of fatigue detection methods with higher accuracy, but the basic correlation ...
Hui Zhang, Dingan Ni, Naikan Ding, Yifan Sun, Qi Zhang, Xin Li   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Transit Signal Priority Strategy With Right-Turn Lane Sharing

IEEE Access, 2020
Transit signal priority (TSP) has become an increasingly popular way to tackle bus operation issues. Many efforts have been conducted to design TSP strategies, yet challenges still exists in real-life applications due to the difficulty in realizing the ...
Wenming Rao, Weitao Lyu, Zhenbo Lu, Jingxin Xia   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Investigation and Analysis of the Acceptance of the License Plate–Based Restriction Policy: A Case Study in Hangzhou, China

Journal of Advanced Transportation
In order to better understand the factors that affect Hangzhou residents’ acceptance of the license plate–based restriction (LPR) policy, new factors such as fairness, family life cycle factors, and preacceptance of alternative measures were added to ...
Yexing Yin, Gang Yu, Rongchuan Lin, Sheng Jin, Cheng Xu   +4 more
doaj   +1 more source

Analysis of Key Commuting Routes Based on Spatiotemporal Trip Chain

Journal of Advanced Transportation, 2022
Commuting pattern is one of the most important travel patterns on the road network; the analysis of commuting pattern can provide support for public transport system optimization, policy formulation, and urban planning.
Wenbin Yao, Caijun Chen, Hongyang Su, Nuo Chen, Sheng Jin, Congcong Bai   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source