Results 41 to 50 of about 305,322 (303)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigation and Analysis of the Acceptance of the License Plate–Based Restriction Policy: A Case Study in Hangzhou, China

Journal of Advanced Transportation
In order to better understand the factors that affect Hangzhou residents’ acceptance of the license plate–based restriction (LPR) policy, new factors such as fairness, family life cycle factors, and preacceptance of alternative measures were added to ...
Yexing Yin, Gang Yu, Rongchuan Lin, Sheng Jin, Cheng Xu   +4 more
doaj   +1 more source

A Review of Pavement Condition Evaluation Index Systems in China and Abroad

Zhongwai Gonglu
With the increasingly complex operating conditions of roads, it has become a consensus among countries to improve the accuracy and systematicness of maintenance decisions.
CHEN Leilei, YANG-LI Wenyun, LI Wei, Muhammad Thlha, QIAN Zhendong   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Driving Fatigue Prediction Model considering Schedule and Circadian Rhythm

Journal of Advanced Transportation, 2020
Driver fatigue level was considered an accumulated result contributed by circadian rhythms, hours of sleep before driving, driving duration, and break time during driving.
Qi Zhang, Chaozhong Wu, Hui Zhang
doaj   +1 more source

Investigation of Air Transportation Technology at Princeton University, 1989-1990 [PDF]

, 1990
The Air Transportation Technology Program at Princeton University proceeded along six avenues during the past year: microburst hazards to aircraft; machine-intelligent, fault tolerant flight control; computer aided heuristics for piloted flight ...
Stengel, Robert F.
core   +1 more source

Transportation in Social Media: an automatic classifier for travel-related tweets

, 2017
In the last years researchers in the field of intelligent transportation systems have made several efforts to extract valuable information from social media streams.
Pasquali, Arian, Pereira, João, Rossetti, Rosaldo, Saleiro, Pedro   +3 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A Hierarchical Control Framework for Coordinating CAV-Dedicated Lane Allocation and Signal Timing at Isolated Intersections in Mixed Traffic Environments

Journal of Advanced Transportation
With the rapid development of connected and automated vehicles (CAVs), numerous studies have demonstrated that CAV-dedicated lanes (CAV-DLs) can significantly enhance traffic efficiency. However, most existing studies primarily focus on optimizing either
Feng Chen, Cunbao Zhang, Yu Cao
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source