Results 71 to 80 of about 39,951 (262)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The sensitivity and specificity of using a computer aided diagnosis program for automatically scoring chest X-rays of presumptive TB patients compared with Xpert MTB/RIF in Lusaka Zambia. [PDF]

, 2014
OBJECTIVE: To determine the sensitivity and specificity of a Computer Aided Diagnosis (CAD) program for scoring chest x-rays (CXRs) of presumptive tuberculosis (TB) patients compared to Xpert MTB/RIF (Xpert).
Ayles, Helen, Rosanna Spooner, Monde Muyoyeta, Laurens Hogeweg, Maureen Moyo, Muyoyeta, Monde, Spooner, R., Pragnya Maduskar, van Ginneken, Bram, Spooner, Rosanna, Bram van Ginneken, Kasese, N., Hogeweg, L., Moyo, Maureen, Kapata, N., Milimo, Deborah, Kapata, Nathan, Helen Ayles, Kasese, Nkatya, Ayles, H., Hogeweg, Laurens, Maduskar, P., Nathan Kapata, Muyoyeta, M., Moyo, M., Nkatya Kasese, Deborah Milimo, Ginneken, B. van, Maduskar, Pragnya, Milimo, D.   +29 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Barking up the wrong biomarker? Correspondence to Shobeiri et al. (2022) “Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis”

Journal of Eating Disorders, 2022
Despite intensified research efforts into the underlying (neuro-)biology of eating disorders (EDs), only few reliable biomarkers of diagnostic or prognostic value have been identified to date.
Jonas L. Steinhäuser, Marie-Louis Wronski, Johanna L. Keeler, Stefan Ehrlich, Joseph A. King   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies. [PDF]

, 2011
BACKGROUND: The World Health Organization recommends the screening of all people living with HIV for tuberculosis (TB) disease, followed by TB treatment, or isoniazid preventive therapy (IPT) when TB is excluded.
Grant, Alison D, Kevin P. Cain, Charles M Heilig, Kimerling, Michael, Varma, Jay K, Kimerling Michael, Lawn, Stephen D, Elizabeth L Corbett, Getahun, Haileyesus, Granich, Reuben, Maartens Gary, Gavin J. Churchyard, Varma Jay K., Maartens, Gary, Wanitchaya Kittikraisak, Alison D Grant, Kittikraisak Wanitchaya, Lawn Stephen D., Elizabeth L. Corbett, Corbett, Elizabeth L, Helen Ayles, Stephen D. Lawn, Kevin P Cain, Corbett Elizabeth L., Date Anand A., Kittikraisak, Wanitchaya, Charles M. Heilig, Jay K. Varma, Wood, Robin, Michael Kimerling, Cain, Kevin P, Churchyard Gavin J., Anand A. Date, Getahun Haileyesus, Ayles, Helen, Shah Sarita, Jay K Varma, Haileyesus Getahun, Ayles Helen, Reuben Granich, Churchyard, Gavin J, Grant Alison D., Robin Wood, Stephen D Lawn, Date, Anand A, Heilig, Charles M, Heilig Charles M., Anand A Date, Gary Maartens, Granich Reuben, Shah, Sarita, Alison D. Grant, Wood Robin, Gavin J Churchyard, Sarita Shah, Cain Kevin P.   +55 more
core   +1 more source

Recent Methods for Retrofitting Heat Exchanger Networks with Heat Transfer Intensifications

Chemical Engineering Transactions, 2014
This paper presents an overview of recent optimization approaches for retrofitting heat exchanger networks (HENs) with heat transfer intensified techniques.
M. Pan, I. Bulatov, R. Smith
doaj   +1 more source

Profile of partners who completed HIV testing and received a new HIV diagnosis in Ukraine’s HIV index testing program: a retrospective cohort study to inform program improvement

BMC Infectious Diseases, 2023
Background Approximately one-third of people living with HIV in Ukraine are unaware of their HIV status. Index testing (IT) is an evidence-based HIV testing strategy that supports voluntary notification of partners with HIV risk, so they can receive HIV ...
Nancy Puttkammer, Alyona Ihnatiuk, Anna Shapoval, Anna Kazanzhy, Andrew Secor, Solmaz Shotorbani, Misti McDowell, Matthew Golden   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source