Results 111 to 120 of about 1,561,159 (250)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Radiobiological Comparison of Intensity-modulated Radiotherapy Using Cobalt-60 and 6 MV Linear Accelerator in Head and Neck Cancers

Journal of Radiation and Cancer Research
Purpose of the Research: This study aims to compare the radiobiological effectiveness of intensity-modulated radiotherapy (IMRT) plans generated using the eclipse treatment planning system (TPS) with 6 MV X-rays from a linear accelerator (Linac) against ...
Mohsin Rehman Khan, Malik Mohib-ul Haq, Malik Tariq Rasool   +2 more
doaj   +1 more source

Localized prostate cancer treated with intensity-modulated radiotherapy

, 2006
AIMS AND BACKGROUND: The development and use of new radiotherapy techniques, especially 3D conformal radiotherapy or intensity-modulated radiotherapy, has allowed the safe application of high doses of external beam radiotherapy without increasing ...
Simontacchi, Gabriele, Mauro Gacci, Bastiani, Paolo, Banci Buonamici, Fabrizio, Mungai, Raffaello, Mondaini, Nicola, Biti, Giampaolo, Ponticelli, Pietro, Gabriele Simontacchi, PAIAR, FABIOLA, Pertici, Maurizio, Paolo Bastiani, Gacci, Mauro, Lorenzo Livi, Giampaolo Biti, Livi, Lorenzo, Detti, Beatrice, Raffaello Mungai, Nicola Mondaini, Federico Nelli, Maurizio Pertici, Pietro Ponticelli, Fabiola Paiar, Nelli, Federico, Fabrizio Banci-Buonamici, Beatrice Detti   +25 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Designed Phase Mask for Suppressing the Inter-Pixel Crosstalk Noise in Intensity-Modulated Multilevel Holographic Data Storage Systems

Photonics
Intensity-modulated signals have the advantage of being directly detectable by the image sensor but have the drawback that the signal quality is easily deteriorated by crosstalk noise, in contrast to phase-modulated signals.
Takuya Nonaka, Soki Hirayama, Tsutomu Shimura, Ryushi Fujimura   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Advances in Intensity-Modulated Radiotherapy Delivery

, 2008
Fixed-field intensity-modulated treatments, delivered by conventional linac-plus-multileaf systems, have rapidly become the most common form of IMRT. Several innovative alternative IMRT options are also now available, including tomotherapy, CyberKnife and jaws-only linacs. These innovative approaches have divergent rationales.
Fenwick, J, Riley, S, Scott, A
openaire   +3 more sources