Results 131 to 140 of about 162,915 (338)

Comparison of simple and complex liver intensity modulated radiotherapy

Radiation Oncology, 2010
Background Intensity-modulated radiotherapy (IMRT) may allow improvement in plan quality for treatment of liver cancer, however increasing radiation modulation complexity can lead to increased uncertainties and requirements for quality assurance.
Eccles Cynthia L, Purdie Thomas G, Lee Mark T, Sharpe Michael B, Dawson Laura A   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An audit of setup reproducibility in radiotherapy of head and neck cancers

Journal of Radiation and Cancer Research, 2016
Background: The use of a customized immobilization thermoplastic mask is essential to compute clinical target volume (CTV) to planning target volume (PTV) margins.
Mranalini Verma, Abdul Aziz Sait, S K Senthil Kumar, K J Maria Das, Punita Lal, Shaleen Kumar   +5 more
doaj   +1 more source

The Changing Therapeutic Role of Chemo-radiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma from Two/Three-Dimensional Radiotherapy to Intensity-Modulated Radiotherapy: A Network Meta-Analysis

Theranostics, 2017
Purpose: We used randomized trials of radiotherapy (RT) with or without chemotherapy in non-metastatic nasopharyngeal carcinoma to investigate the survival benefit of chemoradiotherapy regimens between two/three-dimensional radiotherapy (2D/3D RT) and ...
Rui You, Ying Cao, Pei-yu Huang, Lei Chen, Qi Yang, You-Ping Liu, X. Zou, Yi-Nuan Zhang, Rou Jiang, Mengxia Zhang, Chongyang Duan, A. Lin, M. Hong, Ming-Yuan Chen   +13 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Breast-conserving radiotherapy with simultaneous integrated boost; field-in-field three-dimensional conformal radiotherapy versus inverse intensity-modulated radiotherapy – A dosimetric comparison: Do we need intensity-modulated radiotherapy?

South Asian Journal of Cancer, 2018
Background and Purpose: To examine the feasibility of improving breast-conserving radiotherapy with simultaneous integrated boost (SIB) and analyzing the efficiency of forward versus inverse intensity-modulated radiotherapy (IMRT) techniques in providing
Bindhu Joseph, Nisma Farooq, Sabari Kumar, C R Vijay, Kurian J Puthur, C Ramesh, Vishwanath Lokesh   +6 more
doaj   +1 more source

RELATIONSHIP BETWEEN INTENSITY MODULATED RADIOTHERAPY FOR BUCCAL MUCOSAL TUMORS AND DRY EYE

, 2023
THANUJA P GOPAL, KIRTI KOUSHIK, AYNALA ANUSHA   +2 more
openalex   +1 more source

Clinical evaluation of intensity-modulated radiotherapy for locally advanced pancreatic cancer

Radiation Oncology, 2018
The purpose was to retrospectively evaluate the effect of intensity-modulated radiotherapy (IMRT) on gastrointestinal (GI) toxicities and outcomes compared to three-dimensional conformal radiotherapy (3DCRT) for locally advanced pancreatic cancer (LAPC).
Y. Goto, A. Nakamura, R. Ashida, K. Sakanaka, S. Itasaka, K. Shibuya, S. Matsumoto, M. Kanai, H. Isoda, T. Masui, Y. Kodama, K. Takaori, M. Hiraoka, T. Mizowaki   +13 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source