Results 61 to 70 of about 74,804 (273)

Beam Orientation Optimization for Intensity Modulated Radiation Therapy using Adaptive l1 Minimization

, 2011
Beam orientation optimization (BOO) is a key component in the process of IMRT treatment planning. It determines to what degree one can achieve a good treatment plan quality in the subsequent plan optimization process.
Bortfeld T, Bortfeld T, Chartrand R Sidky E Y Xiaochuan P, Chunhua Men, Djajaputra D, Fung G M, Haas O C L, Li Y J, Meedt G, Men C, Schreibmann E, Steve B Jiang, Woudstra E, Xun Jia, Yifei Lou, Zhu L   +15 more
core   +1 more source

Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. [PDF]

, 2015
The purpose of this study was to evaluate the performance of a commercially available CyberKnife system with a multileaf collimator (CK-MLC) for stereotactic body radiotherapy (SBRT) and standard fractionated intensity-modulated radiotherapy (IMRT ...
Descovich, Martina, Gottschalk, Alexander R, Lessard, Etienne, McGuinness, Christopher M, Nakamura, Jean L, Pinnaduwage, Dilini, Pouliot, Jean, Sims, Colin   +7 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An efficacy of protection the organs at risks comparison between the intensitymodulated radiotherapy therapy (IMRT) and the three-dimensional conformal radiotherapy (3DCRT)

Journal of the Pakistan Medical Association
Objective: To compare the efficiency of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy techniques. Method: The cross-sectional study was conducted from February to August 2021 at Al-Amal National Hospital, Baghdad,
Abd Al-Taj Abd Ali Khaleel, Siham Sabah Abdullah, Sabbar Shukri Al-Bayaty, Abdulrahman Mohammed Abdulbaqi, Nabaa Mohammad Ali Alazawy   +4 more
doaj   +1 more source

Application of Simultaneous Integrated Boost Intensity Modulated Radiotherapy in Locally Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2019
Background and objective The standard treatment for locally advanced non-small cell lung cancer (NSCLC) is radiotherapy concurrent with chemotherapy, but the survival was not satisfied.
Jing YOU, Dan YANG, Dongming LI, Leilei JIANG, Rong YU, Huiming YU, Bo XU, Weihu WANG, Anhui SHI   +8 more
doaj   +1 more source

Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix

Journal of Clinical and Scientific Research, 2018
Background: Cervical cancer is the most common gynecological cancer among Indian women. 3D-CRT treatment is associated with more acute and late toxicities, because of close proximity of bladder and rectum to the cervix.
Revathi Badiginchala, Swapna Jilla, B V Subramanian, Prana Bandhu Das, Archana Prathipati, G Sanjeeva Kumar   +5 more
doaj   +1 more source

Performance Comparison of Knowledge-Based Dose Prediction Techniques Based on Limited Patient Data. [PDF]

, 2018
PurposeThe accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and ...
Landers, Angelia, Neph, Ryan, Ruan, Dan, Scalzo, Fabien, Sheng, Ke   +4 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Ovarian Transposition Strategy in Patients with Cervical Cancer Who Undergo Pelvic Radiation: Proposal of Ovarian Placement Based on Virtual Simulations

European Medical Journal Innovations, 2021
Objective: To establish a proposal for the location for ovarian transposition, considering different irradiation techniques and time to ovarian failure.
Gabriel Oliveira Bernardes Gil, Cassiano Asano, Maria Luísa Braga Vieira Gil, Warne Andrade, Eduardo Batista Cândido, Marcos Regalin, Izabella Nobre Queiroz, Darly Gomes Soares Delfino, Farley Soares Cantídio, Agnaldo Lopes Silva-Filho   +9 more
doaj   +1 more source

GPU-based ultra-fast direct aperture optimization for online adaptive radiation therapy

, 2010
Online adaptive radiation therapy (ART) has great promise to significantly reduce normal tissue toxicity and/or improve tumor control through real-time treatment adaptations based on the current patient anatomy.
Bazaraa M, Bentley J, Chunhua Men, Earl M A, Fox C, Gu X, Gu X, Hoberock J Bell N, Kokubo M, Langen K M, Li M, Li Y J, Men C, Men C, Steve B Jiang, Wong J R, Wu C, Wu Q J, Xing M Decaudin P Baogang H Xiaopeng Z, Xun Jia, Yan D, Zhang G W   +21 more
core   +1 more source