Results 101 to 110 of about 11,212,414 (344)

Development and Psychometric Evaluation of the PROMIS Pediatric Pain Intensity Measure in Children and Adolescents with Chronic Pain. [PDF]

open access: yesJ Pain, 2021
Mara CA   +10 more
europepmc   +1 more source

Measuring the intensity of emotions

open access: yesFrontiers in Psychology
We describe a theoretical framework for the measurement of the intensity of emotional experiences and summarize findings of a series of studies that implemented this framework. Our approach is based on a realist view of quantities and combines the modern psychometric (i.e., latent-variable) view of measurement with a deductive order of inquiry for ...
Rainer Reisenzein, Martin Junge
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Development of strain gages to analyze the stress intensity factor of a crack tip

open access: yesNihon Kikai Gakkai ronbunshu, 2015
There are currently one or two kinds of strain gages to measure the stress intensity factor. It might not be sometimes easy to analyze the stress intensity factor with those gages.
Shigeru KUROSAKI   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Intensity-Curvature Measurement Approaches for the Diagnosis of Magnetic Resonance Imaging Brain Tumors

open access: yesJournal of Advanced Research, 2015
This research presents signal-image post-processing techniques called Intensity-Curvature Measurement Approaches with application to the diagnosis of human brain tumors detected through Magnetic Resonance Imaging (MRI).
Carlo Ciulla   +3 more
doaj   +1 more source

MEASURING CAREGIVING INTENSITY

open access: yesInnovation in Aging
Abstract This paper discusses measurement of caregiving intensity, using empirical data to illustrate the need to develop a consensus around measurement of this construct. “Caregiving intensity” differs from the related construct, “caregiver burden”, which measures the subjective experience of caregiving; caregiving intensity focuses ...
Nadash, Pamela, Tell, Eileen, Park, Sung
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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