Results 81 to 90 of about 1,032,894 (314)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A simple tool to measure procedural restraint intensity in children: validation of the PRIC (Procedural Restraint Intensity in Children) scale

Heliyon, 2019
Purpose: Restraint is often used when administering procedures to children. However, no metrologically scale to measure the restraint intensity had yet been validated.
Bénédicte Lombart, Daniel Annequin, Patricia Cimerman, Carla De Stefano, Odile Perrin, Celine Bouchart, Marie-Claire Schommer, Laura Ramelot, Céline Petit, Elisabeth Fournier-Charriere, Anne Caron, Solène Trebosc, Barbara Tourniaire, Michel Galinski   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

SENSORY APPROACH TO MEASURE FRAGRANCE INTENSITY ON THE SKIN

, 2009
Sensory analysis is a precise and descriptive measuring technique to quantify human responses to stimuli. Odor, one of these stimuli, is basically the result of the interaction between a chemical stimulus and the olfactory receptor system, which can be ...
CORTEZ-PEREIRA, Claudia Silva, Kaneko, Telma Mary, BABY, Andre Rolim, Velasco, Maria Valeria Robles   +3 more
core   +1 more source

Measurement of Plasmodium falciparum transmission intensity using serological cohort data from Indonesian schoolchildren. [PDF]

, 2013
BACKGROUND: As malaria transmission intensity approaches zero, measuring it becomes progressively more difficult and inefficient because parasite-positive individuals are hard to detect. This situation may arise shortly before achieving local elimination,
Lobo, Neil F, William A Hawley, Drakeley, Chris J, Jackie Cook, Supargiyono, Supargiyono, Wijayanti, Mahardika A, Dian Nugraheni, Supargiyono Supargiyono, Neil F Lobo, Anis N Widyastuti, Widyastuti, Anis N, Hawley, William A, Michael T Bretscher, Cook, Jackie, Bretscher, Michael T, Nugraheni, Dian, Mahardika A Wijayanti, Chris J Drakeley   +17 more
core   +1 more source

Optimal Seismic Intensity Measure Selection for Isolated Bridges under Pulse-Like Ground Motions

Advances in Civil Engineering, 2019
Isolated bridges are commonly designed in the near-fault region to balance excessive displacement and seismic force. Optimal intensity measures (IMs) of probabilistic seismic demand models for isolated bridges subjected to pulse-like ground motions are ...
Linwei Jiang, Jian Zhong, Min He, Wancheng Yuan   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Measure for Measure: How Well Do We Measure Micro-Level Conflict Intensity? [PDF]

, 2011
Rich measures of micro-level violent intensity are jey for succesfully providing insight into the legacy of civil war. Yet, the debate on how exactly conflict intensity should be measured has just started.
Verpoorten, Marijke
core  

A quantitative analysis of transmission efficiency versus intensity for malaria. [PDF]

, 2010
The relationship between malaria transmission intensity and efficiency is important for malaria epidemiology, for the design of randomized control trials that measure transmission or incidence as end points, and for measuring and modelling malaria ...
Chiyaka, Christinah, Smith, DL, Drakeley, Chris J, Chiyaka, C, Smith, David L, David L. Smith, Chris J. Drakeley, Simon I. Hay, Hay, Simon I, Drakeley, CJ, Christinah Chiyaka, Hay, SI   +11 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source