Results 111 to 120 of about 4,889,943 (304)
Bioactive Trace Metal Distributions and Biogeochemical Controls in the Southern Ocean [PDF]
, 2012 Extensive sampling in many regions of the Southern Ocean has demonstrated that surface water concentrations of dissolved Fe are low enough to limit phytoplankton growth. In contrast, there is currently no evidence that other bioactive elements (e.g., Mn,
Measures, Christopher I. +7 more
core +1 more source
BuildingsSelection of the optimal intensity measure is an important contribution to reducing the numerous uncertainties in seismic inputs within the context of performance-based earthquake engineering, especially for unreinforced masonry buildings that exhibit ...
Ante Pilipović +2 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Identifying suitable intensity measures for developing seismic fragility curves of horseshoe tunnels
International Journal of Geo-EngineeringThis study presents a comprehensive framework for selecting optimal ground motion intensity measures (IMs) and developing seismic fragility curves for horseshoe tunnels.
Van-Quang Nguyen +2 more
doaj +1 more source
Applied SciencesResearch on the characterization of ground motion intensity and damage of underground structures is limited, while reasonable selection of ground motion intensity measures and structural damage measures is a crucial prerequisite for structural seismic ...
Tong Liu +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Grading the intensity of nondental orofacial pain: Identification of cutoff points for mild, moderate, and severe pain [PDF]
, 2015 Background: When assessing pain in clinical practice, clinicians often label pain as mild, moderate, and severe. However, these categories are not distinctly defined, and are often used arbitrarily.
Zakrzewska, JM, Brailo, V
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source