Results 91 to 100 of about 4,889,943 (304)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Multiple regression models for KOA pain intensity at baseline for four different pain intensity measures.

, 2020
Multiple regression models for KOA pain intensity at baseline for four different pain intensity measures.
Thomas Schnitzer (70040), Joana Barroso (8269260), Vasco Galhardo (8269269), João Pinto-Ramos (8269266), A. Vania Apkarian (7288406), Kenta Wakaizumi (7207733), Diane Reckziegel (8269263)   +6 more
core   +1 more source

On the measurement of the luminous intensity of light [PDF]

Journal of the Franklin Institute
Abstract The measurement of the luminous intensity of a ray of light is a problem the solution of which has been repeatedly attempted, but with less satisfactory results than the endeavours to measure the other radiant forces. The problem is susceptible of two divisions, the absolute and the relative measurement of light.
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Numerical Experimental Study on Optimizing Control Measures for Geyser Intensity in Baffle-Drop Shafts [PDF]

长江科学院院报
[Objective] This study aims to systematically investigate the control measures for geyser intensity in baffle-drop shafts during the release of high-pressure trapped air pockets. By analyzing the effects of key parameters—including the connection mode of
YANG Qian, YANG Qing-hua, CHEN Feng
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Measuring intensity of end of life care: a systematic review.

PLoS ONE, 2015
BackgroundMany studies have measured the intensity of end of life care. However, no summary of the measures used in the field is currently available.ObjectivesTo summarise features, characteristics of use and reported validity of measures used for ...
Xhyljeta Luta, Maud Maessen, Matthias Egger, Andreas E Stuck, David Goodman, Kerri M Clough-Gorr   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Ground-Motion Intensity Measures for the Seismic Response of the Roof-Isolated Large-Span Structure

Buildings
Ground-motion intensity measures (IMs), which quantify and describe the characteristics of earthquake ground motion, are of utmost importance in the assessment of seismic risk and the design of resilient structures with large spans.
Wei Zhen, Yikun Qiu, Yanhua Zhang, Wei Li   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source