Results 121 to 130 of about 1,998,001 (374)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Interprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study

BMC Anesthesiology, 2019
Background Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a specialised centre before or after ...
Stefan Felix Ehrentraut, Barbara Schroll, Stefan Lenkeit, Heidi Ehrentraut, Christian Bode, Stefan Kreyer, Florian Kögl, Felix Lehmann, Thomas Muders, Martin Scholz, Claudia Strater, Folkert Steinhagen, Nils Ulrich Theuerkauf, Carsten Weißbrich, Christian Putensen, Jens-Christian Schewe   +15 more
doaj   +1 more source

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016. [PDF]

, 2016
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
Aburageila, M, Akcan, U, Akeda, Y, Alexandropoulos, P, Arican, N, Author et al, Bateman, RM, Bilgic Gazioglu, S, Bolton, N, Bonney, S, Borderías, L, Briones, M, Chantziara, V, Chinou, E, De la Torre-Prados, MV, Dinter, C, Douvdevani, A, Dudziak, J, Eilers, B, Ellis, CG, Enguix-Armada, A, Ergin Ozcan, P, Esen, F, Garcia-Alcantara, A, Garcia-De la Torre, A, Georgiou, S, Giris, M, González-Quevedo, N, Hagiya, H, Hawa, H, Herrera-Ramos, E, Hirose, T, Hirose, T, Horcajada, J, Ikeda, T, Ikeda, T, Ikeda, T, Imaizumi, H, Izutani, Y, Izutani, Y, Jagger, JE, Kang, J, Kaya, M, Kodaira, A, Kojima, T, Kubo, T, Kucukerden, M, Lagiou, F, Lott, R, Lotz, J, López-Rodríguez, M, Meili, MM, Micha, G, Michaloudis, G, Naamani, O, Nakamura, Y, O, M, Ogura, H, Ojima, M, Ojima, M, Ono, S, Ono, S, Ono, S, Orhan, N, Orhun, G, Perez-Valero, V, Puerto-Morlan, A, Rajas, O, Riff, R, Rodríguez de Castro, F, Rodríguez Gallego, C, Ruíz-Hernández, J, Salahuddin, N, Schuetz, PS, Senturk, E, Sharpe, MD, Sharshir, M, Shimazu, T, Shimazu, T, Solé-Violán, J, Suda, S, Suda, S, Suda, S, Takahashi, H, Takegawa, R, Taniguchi, T, Tasaki, O, Tomono, K, Tridente, A, Tsimogianni, A, Tuzun, E, Ueno, T, Ueno, T, Ueno, T, Ugur Yilmaz, C, Valta, M, Vassi, A, Wissmann, C, Yamamoto, N, Yoshida, H   +99 more
core  

Follow-up services for improving long-term outcomes in intensive care unit (ICU) survivors [PDF]

, 2017
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Our main objective is to assess the effectiveness of follow-up services for ICU survivors that aim to identify and address unmet health needs related to the ICU ...
Alderson, Phil, Lewis, Sharon R., McPeake, Joanne, Schofield-Robinson, Oliver J., Schofield-Robinson, Oliver J., Smith, Andrew F.   +5 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Grid data mining strategies for outcome prediction in distributed intensive care units [PDF]

, 2013
Previous work developed to predict the outcome of patients in the context of intensive care units brought to the light some requirements like the need to deal with distributed data sources. Those data sources can be used to induce local prediction models
Abelha, António, Machado, José Manuel, Miranda, Miguel, Portela, Filipe, Rua, Fernando, Santos, Manuel Filipe, Silva, Álvaro   +6 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study

Intensive Care Medicine Experimental
Background Acute respiratory distress syndrome (ARDS) is characterised by significant morphological heterogeneity. Morphological sub-phenotyping can potentially be used to personalise mechanical ventilation.
Kristin Jona Bjarnadottir, Martin Tovedal, Gaetano Perchiazzi, Miklos Lipcsey, Lucian Covaciu, Magnus von Seth, Rafael Kawati, Mariangela Pellegrini   +7 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source