Results 141 to 150 of about 1,998,001 (374)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Intensive Care Medicine ExperimentalBackground Extracorporeal membrane oxygenation (ECMO) can alter the pharmacokinetics of diverse antimicrobials, posing challenges in achieving therapeutic drug levels.
Giovanni Camen +9 more
doaj +1 more source
Origins of Neonatal Intensive Care [PDF]
, 2000 This is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,London, on 27 April 1999. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2001.©The Trustee of the Wellcome ...
Christie, DA, Tansey, EM
core
Deprivation of liberty standards in intensive care medicine [PDF]
, 2015 Julian Brown
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
From Mechanical Ventilation to Intensive Care Medicine: A Challenge for Bosnia and Herzegovina
Biomolecules & Biomedicine, 2009 Intensive care medicine is a relatively new specialty, which was created in the 1950's, after invent of mechanical ventilation, which allowed caring for critically ill patients who otherwise would have died.
Guillaume Thiéry +6 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lung and diaphragm ultrasound as predictors of success in weaning from mechanical ventilation
Critical Ultrasound Journal, 2018 Background Lung and diaphragm ultrasound methods have recently been introduced to predict the outcome of weaning from mechanical ventilation (MV).
Eva Tenza-Lozano +3 more
doaj +1 more source
Some prehistory of New Zealand intensive care medicine [PDF]
, 2009 Ronald V. Trubuhovich
openalex +1 more source