A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley +1 more source
European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: A path toward improved patient management. [PDF]
De Backer D, Cecconi M, Ostermann M.
europepmc +1 more source
Characteristics of Older Individuals with Asthma Being Treated with Biologics
Maria Aetou,1,* Yavor Kiskinov,2,* Sitraka Faniry Nantenaina Ratsimba,1 Maximilian Barth,1 Carmen Pizarro,2 Ingmar Bergs,1 Jens Spiesshoefer,1 Dirk Skowasch,2,* Michael Dreher1,* 1Department of Pneumology and Intensive ...
Aetou M +8 more
doaj
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Time-Limited Trials in Intensive Care Medicine: A Tool for Avoiding Inappropriate Treatment. [PDF]
Russwurm M.
europepmc +1 more source
Artificial Intelligence in Intensive Care Medicine: Toward a ChatGPT/GPT-4 Way? [PDF]
Lu Y, Wu H, Qi S, Cheng K.
europepmc +1 more source
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Editorial: Case reports in intensive care medicine 2023. [PDF]
Zhu C, Chen C, Lin B, Yu Y.
europepmc +1 more source
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro +14 more
wiley +1 more source

