Results 101 to 110 of about 2,077,324 (384)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Ethics in the Intensive Care Unit

Tuberculosis and Respiratory Diseases, 2015
The intensive care unit (ICU) is the most common place to die. Also, ethical conflicts among stakeholders occur frequently in the ICU. Thus, ICU clinicians should be competent in all aspects for ethical decision-making. Major sources of conflicts are behavioral issues, such as verbal abuse or poor communication between physicians and nurses, and end-of-
Ju-Ock Kim, Jae Young Moon
openaire   +3 more sources

UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease

Applied Bionics and Biomechanics
Background. Moyamoya disease (MMD) leads to nerve injury. Exosomes are touted as bio-shuttles for the delivery of distinct biomolecules inside the cells. Recently, UCH-L1 was shown to play a vital role in nerve injury.
Minghua Xu, Xiaomin Zhao, Jiang Zhao, Zhisheng Tan, Chengshi Zhang, Yun Huang, Huiping Zhong, Meifeng Guo, Chen Zhang, Ping Ye, Wentao Zheng   +10 more
doaj   +1 more source

Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Italian Journal of Pediatrics, 2020
Introduction The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals.
Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, Neuroprem Working Group, Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, Alessandra Boncompagni   +36 more
doaj   +1 more source

Quantitative Pupillometry in the Intensive Care Unit

Journal of Intensive Care Medicine, 2019
Quantitative pupillometry provides a noninvasive and objective assessment within the neurological examination. This review details the physiology of the pupillary light response, the clinical significance of changes in pupillary reactivity, and the ...
M. Bower, A. Sweidan, Jordan C. Xu, Sara Stern-Neze, Wengui Yu, Leonid I. Groysman   +5 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021

Annals of Intensive Care, 2021
Intensive care unit professionals have experience in critical care and its proportionality, collegial decision-making, withholding or withdrawal of treatment deemed futile, and communication with patients’ relatives. These elements rely on ethical values
Olivier Lesieur, Jean Pierre Quenot, Zoé Cohen-Solal, Raphaëlle David, Laure De Saint Blanquat, Maxime Elbaz, Bénédicte Gaillard Le Roux, Cyril Goulenok, Sylvain Lavoué, Virginie Lemiale, Emmanuelle Mercier, Chaouki Mezher, Benoît Misset, Gwendolyn Penven, Anne Laure Poujol, Bertrand Quentin, Régis Quéré, Thierry Van Der Linden, Jean Philippe Rigaud   +18 more
doaj   +1 more source

Beyond p‐values: Assessing clinical significance in acupuncture research

Advanced Chinese Medicine, EarlyView.
Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
wiley   +1 more source

Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: A prospective, multicenter propensity analysis [PDF]

, 2011
To analyze the impact of decannulation before intensive care unit discharge on ward survival in nonexperimental conditions. DESIGN: Prospective, observational survey.
Fernandez, R. (Rafael), Frutos, F. (Fernando), Garcia-Sanchez, M. (Manuela), Gomez, M.J. (María Jesús), Gonzalez, J. (Javier), Hernandez, G. (Gonzalo), Ibañez, P. (Pedro), Marcos, A. (Alfredo), Monedero, P. (Pablo), Tizon, A.I. (Ana Isabel), Torre, M.V. (María Victoria) de la   +10 more
core  

Case report: Typhoid fever complicated by hemophagocytic lymphohistiocytosis and rhabdomyolysis [PDF]

, 2015
Hemophagocytic lymphohistiocytosis (HLH) and rhabdomyolysis are rare complications of typhoid fever from Salmonella enterica serovar Typhi. Herein, we describe the clinical features in a 21-year-old female from India who presented to the intensive care ...
Despotovic, Vladimir, Esmaeeli, Amir, Non, Lemuel R, Patel, Rupa   +3 more
core   +2 more sources