Results 81 to 90 of about 1,218,126 (318)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Update of Sepsis in the Intensive Care Unit

Journal of Innate Immunity, 2017
Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an increased incidence and prevalence over the last years with a simultaneous decrease in its short-term mortality.
K. Genga, J. Russell
semanticscholar   +1 more source

Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening

Aging and Cancer, EarlyView.
ABSTRACT Background Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age‐related changes in ...
Mehran Radak, Armin Sharifi, Derek Richard, Hossein Fallahi   +3 more
wiley   +1 more source

Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis

Journal of Inflammation Research
Anwaier Apizi,* Jian Li,* Paiheriding Kamilijiang, Chun-Bo Yang, Zheng-Kai Wang, Rui-Feng Chai, Zhao-Xia Yu Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic
Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX   +6 more
doaj  

Assessment of fluid responsiveness in spontaneously breathing patients: a systematic review of literature

Annals of Intensive Care, 2018
Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior to volume expansion is critical to avoid fluid overload, which has been ...
Renato Carneiro de Freitas Chaves, Thiago Domingos Corrêa, Ary Serpa Neto, Bruno de Arruda Bravim, Ricardo Luiz Cordioli, Fabio Tanzillo Moreira, Karina Tavares Timenetsky, Murillo Santucci Cesar de Assunção   +7 more
doaj   +1 more source

Associations Between Dysphagia and Adverse Health Outcomes in Older Adults with Dementia in Intensive Care Units: A Retrospective Cohort Study

, 2023
Hongtao Cheng, Xingwen Deng, Jieyao Li, Yonglan Tang, Shiqi Yuan, Xiaxuan Huang, Zichen Wang, Fuling Zhou, Jun Lyu   +8 more
openalex   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Analysis of the concept of nurses’ autonomy in intensive care units: A hybrid model

, 2023
Fariba Taleghani, Raziye Dehbozorgi, Monire Babashahi, Sharife Monemian, Masoume Masoumi   +4 more
openalex   +2 more sources

Streptococcal toxic shock syndrome in the intensive care unit

Annals of Intensive Care, 2018
The streptococcal toxic shock syndrome is a severe complication associated with invasive infections by group A streptococci. In spite of medical progresses in the care of patients with septic shock during the last decades, this condition has remained ...
M. Schmitz, X. Roux, B. Huttner, J. Pugin   +3 more
semanticscholar   +1 more source

The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey, Ahmad A. Toubasi, Jiacheng Wang, Habeeb F. Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A. Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato   +17 more
wiley   +1 more source