Results 131 to 140 of about 113,262 (301)

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Dose individualisation of antibiotics in critically ill patients with inflammation: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Due to extensive pathophysiological changes in critically ill patients, standard dosing of antibiotics may lead to inadequate drug exposure. This is concerning, as insufficient plasma drug concentrations may lead to treatment failure, whereas excessive drug exposure may increase the risk of toxic adverse events.
Sarah Dräger, Iris K. Minichmayr, Narges Alipanah‐Lechner, Erin F. Barreto, Lieuwe D. J. Bos, Lucas M. Fleuren, Nicole G. M. Hunfeld, Sumith K. Mathew, Sophie L. Stocker, João Paulo Telles, Antoni Torres, Birgit C. P. Koch, Henrik Endeman   +12 more
wiley   +1 more source

The Role of Physiotherapy in a Neonatal Intensive Care Unit

Australian Journal of Physiotherapy, 1988
The role of physiotherapy in the neonatal intensive care unit has historically been mainly associated with the care of the neonate's lungs. Postural drainage coupled with percussion, vibrations and suction are all used in the physiotherapy management of neonatal respiratory disorders.
openaire   +3 more sources

Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin

Cytoskeleton, EarlyView.
ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro, Shashank Shekhar, Stefanie M. Novak, Sudipta Biswas, Carol C. Gregorio, Velia M. Fowler   +5 more
wiley   +1 more source

Biallelic NEXN variants and fetal onset dilated cardiomyopathy: two independent case reports and revision of literature

Italian Journal of Pediatrics
Background Dilated cardiomyopathy (DCM) is an etiologically heterogeneous group of diseases of the myocardium. With the rapid evolution in laboratory investigations, genetic background is increasingly determined including many genes with variable ...
Irene Picciolli, Angelo Ratti, Berardo Rinaldi, Anwar Baban, Maria Iascone, Gaia Francescato, Alessia Cappelleri, Monia Magliozzi, Antonio Novelli, Giovanni Parlapiano, Anna Maria Colli, Nicola Persico, Stefano Carugo, Fabio Mosca, Maria Francesca Bedeschi   +14 more
doaj   +1 more source

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger, Carina Holmqvist, Daniël M. Jonker, Bjarke M. Klein, Lorien E. Urban   +4 more
wiley   +1 more source

The Duration of Hospitalization and Readmission Rate of Low Birth Weight Infants in a Tertiary Referral Hospital in Isfahan, Iran [PDF]

Iranian Journal of Neonatology, 2015
Background: Currently, the number of premature deliveries has been increasing, resulting in early postnatal discharge due to shortage of beds in the neonatal intensive care units (NICU).
Amir-Mohammad Armanian, Majid Mohammadzadeh, Razieh Soleimani, Nima Salehimehr, Akbar Hasanzadeh   +4 more
doaj  

Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges

Clinical Pharmacology &Therapeutics, EarlyView.
Barriers to incorporating pharmacogenetics into routine clinical practice in the United States are well documented. Initial surveys by the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2009 and 2010 identified barriers across four key domains that have hindered the widespread adoption of clinical pharmacogenetic testing.
D. Max Smith, Michael P. Douglas, Christina L. Aquilante, Patricia A. Deverka, Beth Devine, Henry M. Dunnenberger, Philip E. Empey, Daniel L. Hertz, Andrew A. Monte, Ann M. Moyer, Jai N. Patel, Victoria M. Pratt, Loren Saulsberry, Stuart A. Scott, Deepak Voora, Erica L. Woodahl, Michelle Whirl‐Carrillo, Akinyemi Oni‐Orisan, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +18 more
wiley   +1 more source

Developmental Care: assistance of nurses from Neonatal Intensive Care Units

Revista Brasileira de Enfermagem
Objective: to analyze the Developmental Care in nursing care for Newborns in critical Neonatal Intensive Care Units. Method: a qualitative study with 11 nurses from Neonatal Intensive Care Units of a city in the State of São Paulo countryside, based on ...
Bruna de Souza Lima Marski, Beatriz Castanheira Facio, Sueli Mutsumi Tsukuda Ichisato, Patricia Carla de Souza Della Barba, Monika Wernet   +4 more
doaj   +1 more source

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients

Drug Testing and Analysis, EarlyView.
This study investigated the incorporation of novel and traditional medically used opioids into the hair of 118 pediatric and neonatal patients. Concentrations (median [range]) in hair were as follows: fentanyl: 4.03 pg/mg [0.10–343], sufentanil: 0.31 pg/mg [0.10–8.64], remifentanil: 0.14 pg/mg [0.10–0.43], and morphine: 27.4 pg/mg [1.0–1870].
Max Polke, Florian Zapf, Tanja Restin, Thomas Kraemer, Tina M. Binz   +4 more
wiley   +1 more source