Results 61 to 70 of about 6,110,800 (292)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Hand hygiene adherence in intensive care units: comparison before and during the COVID-19 pandemic in a municipality of São Paulo state [PDF]

Einstein (São Paulo)
Objective: Compare alcohol-based hand sanitizer use in intensive care units in a municipality in São Paulo state, before and during the coronavirus pandemic. Methods: Analytical retrospective study using indirect documentation, with data obtained from a
Vanessa Aparecida Vilas-Boas, Pedro Antonio Teodoro de Moraes, Marcela Grispino Vieira Torres de Lolo, Edinêis de Brito Guirardello, Maria Isabel Pedreira de Freitas   +4 more
doaj   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Predicting death and readmission after intensive care discharge [PDF]

, 2008
Background: Despite initial recovery from critical illness, many patients deteriorate after discharge from the intensive care unit (ICU). We examined prospectively collected data in an attempt to identify patients at risk of readmission or death after ...
B.H. Cuthbertson, J.A. Cook, A.J. Campbell, Cuthbertson, BH, Cook, Jonathan Alistair, Adey, Gillian, Campbell, AJ, Cook, JA, Campbell, Alison J., Cuthbertson, Brian, G. Adey, Adey, G   +11 more
core   +1 more source

Assessment of Nurses’ Knowledge and Practices regarding Liberation Bundle in Pediatric Intensive Care Unit [PDF]

Egyptian Journal of Health Care
Background: Recent critical care guidelines recommended the evidence-based liberation bundle for patients at pediatric intensive care unit. However, limited information is available on the the bundle in Egyptian hospitals. Aim: This study aimed to assess
Reem Mohamed Seddik Ali, Asmaa Nasreldin Mosbeh, Mona Mohamed Hafez   +2 more
doaj   +1 more source

Patient-centred nursing, compassion satisfaction and compassion fatigue in Australian intensive care units [PDF]

, 2018
University of Technology Sydney. Faculty of Health.Aim: To develop a conceptual framework outlining processes involved in patient-centred nursing and compassion satisfaction or compassion fatigue in the context of critical care nursing.
Jakimowicz, Samantha Jane
core  

A deep learning model for real-time mortality prediction in critically ill children

Critical Care, 2019
Background The rapid development in big data analytics and the data-rich environment of intensive care units together provide unprecedented opportunities for medical breakthroughs in the field of critical care.
Soo Yeon Kim, Saehoon Kim, Joongbum Cho, Young Suh Kim, In Suk Sol, Youngchul Sung, Inhyeok Cho, Minseop Park, Haerin Jang, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn   +11 more
doaj   +1 more source

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

Assessment of Nurses' Performance Regarding Care of Children Undergoing Mechanical Ventilation [PDF]

Egyptian Journal of Health Care, 2016
Mechanical ventilation is one of the most common therapies in the newborn intensive careunits. Nursing care for ventilator pediatric patients which include: review communications, checkventilator settings and modes, suction appropriately, assess pain and
Nabila Hassan Abed Ella, Mohamed Mohamed Elmazahy, Amal Ahmad Khalil, Osama Elshahat Mostafa   +3 more
doaj   +1 more source