Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
The Effect of Clinical Supervisors Education to Quality of Nursing Care of Patients under Mechanical Ventilation in Critical Care Units [PDF]
Background & Objective: Nursing care plan in ICU patients is one of the important elements in nursing care, and one of the main strategies is promotion of education level, specially use of supervisors roles as a clinical educator in staff education ...
هاشمی بی ریا, بتول +4 more
core
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Standards for the level of nurse staffing in critical care units [PDF]
The gold standard for nurse staffing levels in critical care in the United Kingdom has been established since 1967 at one nurse for each patient. Recent evidence suggests however that there is a great deal of difference in the staffing levels and skill ...
Gibson, Vanessa
core
Kawasaki disease shock syndrome: a severe form of Kawasaki disease
Kawasaki disease is a systemic vasculitis, primarily encountered in children. Its clinical presentation is well known, and coronary artery abnormalities are classical complications. Shock is not a common form of presentation of the disease.
Rana İşgüder +6 more
doaj
Hyperbaric treatment for acute carbon monoxide poisoning in a patient with beta-thalassemia. [PDF]
Carbon monoxide (CO) poisoning is a rare but potentially devastating event and remains the most common cause of poisoning in developed countries. Diagnosis is often missed or delayed, as the clinical presentation can be highly variable and characterized ...
V. Zanon +8 more
doaj +1 more source
Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran +13 more
wiley +1 more source
Determining the Difficulties of Parents with Children in Home Care Who Were Discharged from Intensive Care [PDF]
Introduction: This study was performed to determine the difficulties experienced by parents with children in home care who were discharged from intensive care.
Gülzade Uysal +15 more
core +1 more source

