Results 41 to 50 of about 969,027 (312)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Offline Safe Reinforcement Learning for Sepsis Treatment: Tackling Variable-Length Episodes with Sparse Rewards

Human-Centric Intelligent Systems
In critical medicine, data-driven methods that assist in physician decisions often require accurate responses and controllable safety risks. Most recent reinforcement learning models developed for clinical research typically use fixed-length and very ...
Rui Tu, Zhipeng Luo, Chuanliang Pan, Zhong Wang, Jie Su, Yu Zhang, Yifan Wang   +6 more
doaj   +1 more source

Can hypnosis and virtual reality reduce anxiety, pain and fatigue among patients who undergo cardiac surgery: a randomised controlled trial

Trials, 2020
Background Different non-pharmacological techniques, including hypnosis and virtual reality (VR) are currently used as complementary tools in the treatment of anxiety, acute and chronic pain.
Floriane Rousseaux, Marie-Elisabeth Faymonville, Anne-Sophie Nyssen, Nadia Dardenne, Didier Ledoux, Paul B. Massion, Audrey Vanhaudenhuyse   +6 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Burden of disease and change in practice in Critically Ill Infants with Bronchiolitis [PDF]

, 2017
Bronchiolitis represents the most common cause of non-elective admission to paediatric intensive care units (ICUs)
, Australian & New Zealand Intensive Care Society (ANZICS) Centre, , Australian & New Zealand Intensive Care Society (ANZICS) Paediat, Alexander, Janet, Beca, John, Croston, Elizabeth, Erickson, Simon, Franklin, Donna, Ganu, Subodh, Gelbart, Ben, Schibler, Andreas, Schlapbach, Luregn J., Slater, Anthony, Straney, Lahn, Whitty, Jennifer A., Wilkins, Barry   +14 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

High-frequency power of heart rate variability can predict the outcome of thoracic surgical patients with acute respiratory distress syndrome on admission to the intensive care unit: a prospective, single-centric, case-controlled study

BMC Anesthesiology, 2018
Background The morbidity and mortality of acute respiratory distress syndrome (ARDS) remains high, and the strategic focus of ARDS research has shifted toward identifying patients at high risk of mortality early in the course of illness.
I-Chen Chen, Chew-Teng Kor, Ching-Hsiung Lin, Jane Kuo, Jang-Zern Tsai, Wen-Je Ko, Cheng-Deng Kuo   +6 more
doaj   +1 more source

European intensive care physicians’ experience of infections due to antibiotic-resistant bacteria [PDF]

, 2020
Background Antimicrobial resistance (AMR) compromises the treatment of patients with serious infections in intensive care units (ICUs), and intensive care physicians are increasingly facing patients with bacterial infections with limited or no adequate ...
De Waele, Jan, Friggeri, Arnaud, Garnacho-Montero, José, Gustin, Marie Paule, Jean, Astrid, Kohlenberg, Anke, Lepape, Alain, Monnet, Dominique L., Savey, Anne, Vanhems, Philippe   +9 more
core   +2 more sources

Stress-Related Disorders of Family Members of Patients Admitted to the Intensive Care Unit With COVID-19 [PDF]

, 2022
Timothy Amass, Lauren J. Van Scoy, May Hua, Melanie Ambler, Priscilla Armstrong, Matthew R. Baldwin, Rachelle Bernacki, Mansoor D. Burhani, Jennifer Chiurco, Zara Cooper, Hope Cruse, Nicholas Csikesz, Ruth A. Engelberg, Laura D. Fonseca, Karin Halvorson, Rachel Hammer, Joanna Heywood, Sarah Hochendoner Duda, Jin Huang, Ying Jin, Laura Johnson, Masami Tabata‐Kelly, Emma Kerr, Trevor Lane, Melissa Lee, Keely Likosky, Donald McGuirl, T. Milinic, Marc Moss, Elizabeth L. Nielsen, Ryan Peterson, Sara J. Puckey, Olivia Rea, S. Rhoads, Christina Sheu, Wendy Tong, Pamela Witt, James H. Wykowski, Stephanie Yu, Renee D. Stapleton, J. Randall Curtis   +40 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source