Results 61 to 70 of about 314,392 (318)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Abdominal physical examinations in early stages benefit critically ill patients without primary gastrointestinal diseases: a retrospective cohort study

Frontiers in Medicine
BackgroundGastrointestinal (GI) function is critical for patients in intensive care units (ICUs). Whether and how much critically ill patients without GI primary diseases benefit from abdominal physical examinations remains unknown.
Xiao Cui, Yu Shi, Xinlei He, Mingyuan Zhang, Hua Zhang, Jianhong Yang, Yuxin Leng   +6 more
doaj   +1 more source

NURSING ATTENTION DEMANDS AT A NEONATAL, PEDIATRIC AND GENERAL INTENSIVE CARE UNIT

Cogitare Enfermagem, 2015
Descriptive and quantitative study to identify intensive nursing attention demands and the efforts these professionals make to cope with these demands.
Danilo Marcelo Araujo dos Santos, Francisca Georgina Macedo de Sousa, Thaís Marques Moreira, Andréa Cristina Oliveira Silva, Lorena Carvalho Braga   +4 more
doaj   +1 more source

Prognosis of Patients Transferred From Intensive Care Units to Departments of Chest Diseases and the Factors Affecting Their Prognosis

, 2011
Aim: One-third of deaths due to a critical disease occur after patients are transferred from intensive care units to hospital departments. Some of the deaths occur in patients who are considered not to need further intensive care treatment or that they ...
Serdar Kalemci, Can Sevinc, Hulya Ellidokuz, ELLİDOKUZ, HÜLYA, Kalemci, Serdar, SEVİNÇ, CAN   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pitfalls in the Diagnosis and Management of Invasive Pneumococcal Meningoencephalitis – What We Can Learn From a Case

Clinical Medicine Insights: Case Reports, 2017
Invasive pneumococcal meningitis is a life-threatening infectious disease affecting the central nervous system. It continues to be the most common type of community-acquired acute bacterial meningitides.
Pascale S Grzonka, Raoul Sutter
doaj   +1 more source

The impact of delirium on the prediction of in-hospital mortality in intensive care patients [PDF]

, 2010
Introduction: predictive models, such as acute physiology and chronic health evaluation II (APACHE-II), are widely used in intensive care units (ICUs) to estimate mortality.
Sanne AE Peters, Boogaard, Mark van den, van der Hoeven, J.G., Hoeven, J.G. van der, Boogaard, M.H.W.A. van den, Lisette Schoonhoven, Johannes G van der Hoeven, Peters, M.J., Schoonhoven, L., Leffers, Pieter, Schoonhoven, Lisette, Pickkers, P., van der Hoeven, Johannes G., Leffers, P., Pieter Leffers, Peter Pickkers, Hoeven, Hans van der, Dagnelie, Pieter, Van den Boogaard, M., Mark van den Boogaard, Peters, Sanne A.E., Dagnelie, Pieter C., Pickkers, Peter, Peters, S.A., Dagnelie, P.C., Pieter C Dagnelie   +25 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Does early tracheostomy affect the duration of mechanical ventilation in patients with severe traumatic head injuries?

The Egyptian Journal of Otolaryngology, 2018
Background and purpose Tracheostomy is a surgical procedure performed frequently in intensive care units (ICUs). Prolonged mechanical ventilation (MV) is the main indication for tracheostomy in ICUs.
M. M. Roushdy, H. S. Abdel-Ghaffar, Ahmed Ezzat Mohamed Saleh   +2 more
doaj   +1 more source

Family care in intensive care units

Southern African Journal of Critical Care, 2019
No Abstract.
openaire   +5 more sources