Results 71 to 80 of about 314,392 (318)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Focus on Italian hyperbaric centers: lights and shadows in the pediatric field. [PDF]

Pediatric Anesthesia and Critical Care Journal (PACCJ)
Hyperbaric oxygen therapy (HBOT) is often underesti- mated due to limited awareness of its therapeutic poten- tial and the scarce availability of specialized centers in Italy, whose distribution across the country is highly un- even.
M. Ciuffreda, S. Sorrenti, L. Brugiaferri, E. Pisello, G. Ledda, C. Piangatelli, D. Galante   +6 more
doaj   +1 more source

Optimal productive size of hospital’s intensive care units [PDF]

Hospital, Intensive Care Units, Returns to Scale, Optimal ...
James Moises, Vivian Valdmanis, Hervé Leleu   +2 more
core  

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Wissing, Heimo, Nocea, Gonzalo, Krobot, Karl J., Kaskel, Peter, Ballus, Jose, Bingold, Tobias Michael, Kumar, Ritesh N., Mavros, Panagiotis   +7 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Invasive Mould Infections In Intensive Care Units: Epidemiology, Microbiologic Diagnosis And Antifungal Resistance

, 2019
Invasive fungal infections present with a rising incidence and high morbidity and mortality rates. Among these infections are those due to moulds which draw particular attention per the diagnostic difficulties and higher mortality rates. While a relative
Arikan Akdagli, Sevtap, Sig, Ali Korhan
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Prognostic analysis of acute pancreatitis due to different etiologies and establishment and validation of an early prediction model

Lipids in Health and Disease
Background Acute pancreatitis (AP), an acute inflammatory condition commonly encountered in patients admitted to intensive care unit, is mainly caused by gallstones, alcohol abuse, or hyperlipidemia. Traditional views focus on single-etiology AP; however,
Qiuting Peng, Yunxiang Long, Kun Yang, Kaibo Yang, Jia Jia, Senyi Hu, Chang Liu, Kai Qu, Ting Lin   +8 more
doaj   +1 more source

Identifying Priorities in Intensive Care : a description of a system for collecting intensive care data, an analysis of the data collected, a critique of aspects of severity scoring systems used to compare intensive care outcome, identification of priorities in intensive care and proposals to improve outcome for intensive care patients.

, 1999
MDThis thesis reviews the requirements for intensive care audit data and describes the development of ICARUS (Intensive Care Audit and Resource Utilisation System), a system to collect and analyse intensive care audit information.
Goldhill, David Raymond
core