Results 201 to 210 of about 233,101 (310)

Lake Huron intensive survey, 1980 /

, 1985
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Discrepancy in perceived appropriate and desired resuscitation durations between physicians and laypersons in cardiac arrest patients. [PDF]

J Intensive Care
Tanabe Y, Namba T, Maeda S, Nishikimi M, Ishikawa E, Ohshimo S, Shime N.   +6 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Stakeholder perceptions and planning implications for urban rewilding as a nature-based solution in Poland. [PDF]

Sci Rep
Cirella GT, Kempa J, Paczoski A, Rościszewski-Dodgson MJ.   +3 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Knowledge, attitudes, and practices of ICU physicians on antimicrobial use and resistance: a scoping review. [PDF]

Antimicrob Steward Healthc Epidemiol
Piastrelli FT, Nascimento GM, de Oliveira Junior HA, Valente PK, Boszczowski Í.   +4 more
europepmc   +1 more source

Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers

, 2016
Biren B. Kamdar, Melissa P. Knauert, S.F. Jones, Elizabeth C. Parsons, Sairam Parthasarathy, Margaret A. Pisani   +5 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

National insights on malignant hyperthermia: a SIAARTI survey on clinical practices, preparedness, and future directions. [PDF]

J Anesth Analg Crit Care
Monzani R, Alampi D, Bignami E, Cortegiani A, Giarratano A, Racca F, Sbaraglia F.   +6 more
europepmc   +1 more source