Results 241 to 250 of about 233,101 (310)

Practice Patterns and Trends in Temperature Control After Cardiac Arrest: A Multi-Specialty Survey. [PDF]

J Clin Med
Carr CT, Eckert MB, Bhakta N, Guirgis FW, Hopson C, Maciel CB, Becker TK.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The LINK-Lombardia NeuroIntensive care Network. [PDF]

J Anesth Analg Crit Care
Guglielmi A, Graziano F, Vargiolu A, Amigoni M, Berselli A, Cabrini L, Chieregato A, Dell'Acqua A, Dell'Avanzo G, Fassini P, Galassini E, Gemma M, Grappa E, Gritti P, Iaquaniello C, Mangili P, Mazza GM, Mistraletti G, Muttini S, Nguyen M, Ortolano F, Pagani M, Panzeri C, Piva S, Pressato LS, Rasulo F, Sangalli F, Villa F, Viscone A, Zerbi SM, Zoerle T, Citerio G.   +31 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Respiratory management in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia: a binational analysis of current practice. [PDF]

Eur J Pediatr
Gotchac J, De Witte E, Belaroussi Y, Guichoux J, Dienst T, Brissaud O.   +5 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Management of adult organ donors after brain death in ICU: insights from an Italian survey. [PDF]

J Anesth Analg Crit Care
Deana C, Zanierato M, Biasucci DG, Burgio G, Umbrello M, Mascia L, Vetrugno L, Bignami EG.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Video call program for intensive care patients and their families during the COVID-19 pandemic: A retrospective study. [PDF]

Saudi Med J
AlHumedi H, Al-Dorzi HM, Aldawood A, Almatroud A, Aldawsari M, Banu Khan H, Burrows V, Alanazi SA, Naidv B, January E, Al Zayer S, Yeni Z, Marhoun S, Khoutani H, Maghrabi S, AlZighaibi S, Rabeeah F, Alanazi S, Alghamdi H, Aleem Atassi A, Alkathaami A, Arabi YM.   +21 more
europepmc   +1 more source