Results 81 to 90 of about 49,991 (217)

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. [PDF]

, 2011
OBJECTIVE: To assess the cost effectiveness of giving tranexamic acid (TXA) to bleeding trauma patients in low, middle and high income settings. METHODS: The CRASH-2 trial showed that TXA administration reduces the risk of death in bleeding trauma ...
Shakur Haleema, Cairns, John, CRASH 2 trial collaborators, John Cairns, Haleema Shakur, Cairns John, Carla Guerriero, Perel Pablo, Roberts, Ian, Perel, Pablo, Ian Roberts, null null, Guerriero Carla, Roberts Ian, Guerriero, Carla, Shakur, Haleema, Pablo Perel   +16 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]

, 2012
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Henrich, Dirk, Geiger, Emanuel Valentin, Lehnert, Mark, Marzi, Ingo, Emanuel V. Geiger, Ingo Marzi, Dirk Henrich, Birgit Auner, Auner, Birgit, Borna Relja, Relja, Borna, Mark Lehnert   +11 more
core   +1 more source

Intensive prolonged exposure therapy for chronic PTSD patients following multiple trauma and multiple treatment attempts

European Journal of Psychotraumatology, 2018
Background: Suboptimal response and high dropout rates leave room for improvement of trauma-focused treatment (TFT) effectiveness in ameliorating posttraumatic stress disorder (PTSD) symptoms.
Lotte Hendriks, Rianne A. de Kleine, Theo G. Broekman, Gert-Jan Hendriks, Agnes van Minnen   +4 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Trauma abdominal fechado: manejo na unidade de terapia intensiva em um hospital pediátrico terciário [PDF]

, 2015
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Cuidados Intensivos e Paliativos, Florianópolis, 2015.Objetivo.
Farias, Thiara Cristina de Oliveira Ramos
core  

The role of tonic immobility in trauma treatment

Acta Psychologica
Background: Tonic Immobility (TI) is an involuntary response to extreme stress, linked to the onset and severity of PTSD and potentially interfering with recovery. TI may also occur during re-experiencing of trauma, where it has been shown to mediate the
Suzy J.M.A. Matthijssen, Marc de Boer
doaj   +1 more source

Therapist rotation: a novel approach for implementation of trauma-focused treatment in post-traumatic stress disorder

European Journal of Psychotraumatology, 2018
Background: Trauma-focused treatments (TFTs) for patients with post-traumatic stress disorder (PTSD) are highly effective, yet underused by therapists.Objective: To describe a new way of implementing (adequate use of) TFTs, using a therapist rotation ...
Agnes Van Minnen, Lotte Hendriks, Rianne De Kleine, Gert-Jan Hendriks, Marije Verhagen, Ad De Jongh   +5 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source