Results 1 to 10 of about 28,208 (265)

CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder

Frontiers in Psychiatry, 2023
IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites.
Sheila T. Nagamatsu, Sheila T. Nagamatsu, Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Diana L. Núñez-Rios, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Janitza L. Montalvo-Ortiz, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young   +38 more
doaj   +1 more source

Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From a 40‐Year Study of Men

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Anxiety is linked to elevated risk of cardiometabolic disease onset, but the underlying mechanisms remain unclear. We examined the prospective association of 2 anxiety facets, neuroticism and worry, with cardiometabolic risk (CMR) trajectories
Lewina O. Lee, Kevin J. Grimm, Avron Spiro, Laura D. Kubzansky   +3 more
doaj   +1 more source

The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions

Frontiers in Psychiatry, 2020
United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health needs of this population are lacking. Such data are critical to informing the design
Brienna M. Fogle, Brienna M. Fogle, Jack Tsai, Jack Tsai, Natalie Mota, Natalie Mota, Ilan Harpaz-Rotem, Ilan Harpaz-Rotem, John H. Krystal, John H. Krystal, Steven M. Southwick, Steven M. Southwick, Robert H. Pietrzak, Robert H. Pietrzak, Robert H. Pietrzak   +14 more
doaj   +1 more source

Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [F]FPEB and PET Study in Male and Female Rats

Chronic Stress, 2023
Background Females are twice as likely to experience post-traumatic stress disorder (PTSD) than males, yet specific factors contributing to this greater risk are not fully understood.
Ruth H. Asch, Krista Fowles, Robert H. Pietrzak, Jane R. Taylor, Irina Esterlis   +4 more
doaj   +1 more source

Child Revised Impact of Event Scale (CRIES): Validity and Reliability Study of Turkish Version

Neuropsychiatric Investigation, 2021
Objective: Posttraumatic stress disorder develops in a significant portion of children exposed to traumatic experiences, and it has been reported that there are cases in whom posttraumatic stress disorder has not been detected and treated for many years.
Veysi Çeri, Fırat Hamidi, Burak Çakır, Öznur Bilaç, Mehmet İz, Fatma Betül Ay İz, Ömer Aydemir   +6 more
doaj   +1 more source

The effects of extraversion, social support on the posttraumatic stress disorder and posttraumatic growth of adolescent survivors of the Wenchuan earthquake. [PDF]

PLoS ONE, 2015
The aim of this study was to examine the relationships among extraversion, social support, posttraumatic stress disorder and posttraumatic growth among adolescent survivors of the Wenchuan earthquake.Six hundred thirty-eight participants were selected ...
Xuji Jia, Liuhua Ying, Xiao Zhou, Xinchun Wu, Chongde Lin   +4 more
doaj   +1 more source

How does social support enhance resilience in the trauma-exposed individual?

Ecology and Society, 2015
Although most resilience science has focused on individual-level psychosocial factors that promote individual resilience, theorists and researchers have begun to examine neurobiological and systems-level factors implicated in resilience.
Lauren M. Sippel, Robert H. Pietrzak, Dennis S,. Charney, Linda C. Mayes, Steven M. Southwick   +4 more
doaj   +1 more source

Irrational beliefs in posttraumatic stress responses: A Rational Emotive Behaviour Therapy approach [PDF]

, 2015
The current study aimed to test a key theoretical prediction of Rational Emotive Behaviour Therapy theory by assessing the role of general and trauma-specific irrational beliefs in the prediction of posttraumatic stress responses.
Shevlin, Mark, Adamson, Gary, Hyland, Philip, Boduszek, Daniel   +3 more
core   +1 more source

Experimental Combat-Stress Model in Rats: Histological Examination of Effects on Amelogenesis— A Possible Measure of Diminished Vagal Tone Episodes

Dental Anthropology, 2004
Developmental defects of enamel-stress histomarker rings (accentuated striae) may be a potential measure of diminished vagal tone in research on extreme stress such as exposure to combat. To develop an animal model of this measure, we examined the enamel
H. Stefan Bracha, D. Caroline Blanchard, Jeffrey L. Lloyd-Jones, Andrew Williams, Robert J. Blanchard   +4 more
doaj   +1 more source

The Role of Trauma-Specific Irrational Beliefs and Sociodemographic Risk Factors in Posttraumatic Stress Responses [PDF]

, 2013
Posttraumatic stress responses have been linked to a range of social-cognitive and sociodemographic factors. Rational Emotive Behaviour Therapy suggests that responding to a traumatic life event with a set of irrational beliefs should play a crucial role
Shevlin, Mark, Adamson, Gary, Hyland, Philip, Boduszek, Daniel   +3 more
core   +1 more source