Results 91 to 100 of about 963,191 (312)

The transmission of nosocomial pathogens in an intensive care unit: a space–time clustering and structural equation modelling approach

, 2010
We investigated the incidence of cases of nosocomial pathogens and risk factors in an intensive treatment unit ward to determine if the number of cases is dependent on location of patients and the colonization/infection history of the ward.
Sheridan, E. A., Rushton, Steven, Lanyon, Clare, O'Donnell, Anthony, Shirley, Mark   +4 more
core   +1 more source

The underlying risk of death after myocardial infarction in the absence of treatment. [PDF]

, 2002
BACKGROUND: The underlying risk of death in the absence of treatment after a myocardial infarction (MI) is poorly documented. METHODS: Analysis of 23 published studies in which 14 211 patients were followed prospectively after MI; 6817 deaths were ...
Watt, Hilary C, Wald, Nicholas J, Law, Malcolm R, Malcolm R. Law, Hilary C. Watt, Nicholas J. Wald   +5 more
core   +1 more source

Key Advances in Intensive Care and the Coronavirus Disease-19 Research and Practice Boost

, 2022
Components of intensive care include resuscitation, cardiorespiratory stabilization, reversal of organ/system dysfunction or failure, treatment of the underlying pathology, weaning from external support of vital organs, and supportive interventions (e [..
Mentzelopoulos, Spyros D., Spyros D. Mentzelopoulos, Adamos, George, George Adamos   +3 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

OLDER ADULTS WITH PH NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA: A MONOCENTRIC EXPERIENCE ON CONSECUTIVE PATIENTS AGED MORE THAN 55 YEARS

Mediterranean Journal of Hematology and Infectious Diseases
Background: Treating with curative intent elderly patients affected by acute lymphoblastic leukemia (ALL) is an unmet clinical need. Comorbidities, lower tolerance to organ toxicities, and poor disease-related prognostic features make it difficult to ...
Erika Borlenghi, Tatiana Zollner, Giuseppe Rossi, Chiara Pagani, Michele Malagola, Alessandra Sottini, Diego Bertoli, Mariella Tonelli, Marco Chiarini, Chiara Cattaneo, Rossella Leopaldo, Angela Passi, Lorenzo Masina, Francesca Federico, Carlotta Giupponi, Alessandra Tucci   +15 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Enduring intensity for healing: the patient perspective of intensive outpatient treatment for PTSD

European Journal of Psychotraumatology
Background: Prolonged exposure is widely regarded as a first-line treatment for alleviating symptoms of post-traumatic stress disorder (PTSD); however, it is often associated with high dropout rates and may not always be sufficiently efficacious ...
Maria Bragesjö, Volen Z. Ivanov, Sara Farman, Margareta Panagiotidou, Rakel Eklund, Christian Rück   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Screening and treatment of problems after intensive care: a descriptive study of multidisciplinary follow-up

, 2011
OBJECTIVES: To describe a multidisciplinary intensive care follow-up and the methods used for identifying and managing physical and psychological problems in ICU survivors.
Svensson-Raskh, A,, Schandl, AR, Brattström, OR, Falkenhav, MD, Sackey, PV, Hellgren, EM   +5 more
core   +1 more source

Intensive care nurses’ experiences of withdrawal of life-sustaining treatments in intensive care patients: A qualitative study [PDF]

, 2019
To explore the experience of intensive care nurses when participating in the withdrawal of life-sustaining treatments from intensive care unit patients. A qualitative descriptive and explorative design.
Steindal, Simen Alexander, Dihle, Alfhild, Taylor, Ine Henriette Fossum, Hofsø, Kristin   +3 more
core   +1 more source