Results 101 to 110 of about 8,514,767 (300)

Predicting death and readmission after intensive care discharge [PDF]

, 2008
Background: Despite initial recovery from critical illness, many patients deteriorate after discharge from the intensive care unit (ICU). We examined prospectively collected data in an attempt to identify patients at risk of readmission or death after ...
B.H. Cuthbertson, J.A. Cook, A.J. Campbell, Cuthbertson, BH, Cook, Jonathan Alistair, Adey, Gillian, Campbell, AJ, Cook, JA, Campbell, Alison J., Cuthbertson, Brian, G. Adey, Adey, G   +11 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Model-Informed Ceftazidime-Avibactam Dosing Stratified by Renal Function and Renal Replacement Therapy Status in Critically Ill Patients: A Prospective Population Pharmacokinetic and Monte Carlo Simulation Study

Drug Design, Development and Therapy
Juan Hu,1,* Chu-Hui Wang,2,* Xiao-Juan Wang,3 Yong-Wei Yu,1 Jin-Ru Ji,4,5 Wei Zhu,6 Ping Shen,4,5 Yun-Bo Chen,4,5 Xia Zheng,1 Ting-ting Xiao,4,5 Hong-Liu Cai,1 Ya-Lin Dong,2 Yong-Hong Xiao4,51Intensive Care Unit, The First Affiliated ...
Hu J, Wang CH, Wang XJ, Yu YW, Ji JR, Zhu W, Shen P, Chen YB, Zheng X, Xiao TT, Cai HL, Dong YL, Xiao YH   +12 more
doaj  

Home treatment for mental health problems: a systematic review. [PDF]

, 2001
This review investigates the effectiveness of 'home treatment' for mental health problems in terms of hospitalisation and cost-effectiveness. For the purposes of this review, 'home treatment' is defined as a service that enables the patient to be treated
Henderson, J, Burns, T., Wright, C, Watt, H., C. Wright, Henderson, J., T. Burns, Catty, J, Burns, T, Catty, J., H. Watt, Healey, Andrew, J. Catty, Knapp, M, Knapp, Martin, Healey, A, Watt, H, M. Knapp, A. Healey, J. Henderson, Wright, C.   +20 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tagungsband zur 2. Tierwohltagung des Promotionsprogramms „Animal Welfare in Intensive Livestock Production Systems“

, 2019
Am 17. & 18.10.2019 fand in der alten Mensa am Wilhelmsplatz in Göttingen die 2. Tierwohltagung statt, organisiert von den DoktorandInnen des Promotionsprogramms „Animal Welfare in Intensive Livestock Production Sytems“.
Promotionsprogramm „Animal Welfare in Intensive Livestock Production Systems“
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Outcomes of behavioral intervention for children with autism in mainstream pre-school settings [PDF]

, 2011
We evaluated outcomes for 31 children with autism (2–6 years of age at intake) who received behavioral intervention in mainstream pre-school settings and a comparison group of 12 children receiving treatment as usual.
J. Carl Hughes, Hughes, J. Carl, Richard P. Hastings, Jahr, Erik, Hastings, R.P., Eldevik, S., Sigmund Eldevik, Hughes, J.C., Erik Jahr, Hastings, Richard P., Hastings, Richard P.; id_orcid, Jahr, E., Eldevik, Sigmund   +12 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

National Treatment Purchase Fund annual report 2004.

, 2004
The mission of the National Treatment Purchase Fund is to reduce the length of time public patients are on hospital waiting lists by offering them a choice in obtaining access to treatment quickly, safely and to a high standard of patient satisfaction ...
National Treatment Purchase Fund
core