Results 101 to 110 of about 963,191 (312)

Treatment limitation discussions in the intensive care unit with families of patients from culturally diverse backgrounds

, 2022
Introduction: Treatment limitation discussions often take place between intensive care clinicians and families of patients from culturally diverse backgrounds.
Brooks, Laura, Manias, Elizabeth, Bloomer, Melissa   +2 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Vocabulary acquisition during intensive French language learning: the effect of a residential course foe middle school pupils [PDF]

, 1994
The present thesis investigates the evidence for vocabulary development during a period of intensive language work. The research involves a target group of 15 12 year old pupils with 3 .5 years of foreign language learning who participate in a week's ...
Daniels, John Michael
core  

A systematic review of home treatment services--classification and sustainability.

, 2004
BACKGROUND: In view of the plethora of different community-based mental health services, there is a clear need for a classification based on service components rather than labels.
Catty, Jocelyn, Wright, C, Watt, H, Burns, Tom, Watt, Hilary, Wright, Christine, Catty, J, Burns, T   +7 more
core   +1 more source

A randomized trial of hyperglycemic control in pediatric intensive care. [PDF]

, 2014
BACKGROUND: Whether an insulin infusion should be used for tight control of hyperglycemia in critically ill children remains unclear. METHODS: We randomly assigned children (≤16 years of age) who were admitted to the pediatric intensive care unit (ICU ...
Allen, Elizabeth, Grieve, Richard, Morris, Kevin, Sadique, Zia, Parslow, Roger, Elbourne, Diana, CHiP Investigators, Macrae, Duncan, Pappachan, John, Tasker, Robert C   +9 more
core   +1 more source

The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design

Implementation Science, 2018
Background While sepsis-related mortality decreased substantially in other developed countries, mortality of severe sepsis remained as high as 44% in Germany.
Daniel Schwarzkopf, Hendrik Rüddel, Matthias Gründling, Christian Putensen, Konrad Reinhart   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Substance abuse: clinical issues in intensive outpatient treatment.

, 2006
This TIP, Substance Abuse: Clinical Issues in Intensive Outpatient Treatment, was written to help clinicians address the expansion of intensive outpatient treatment (IOT) represented by the development and adoption of new approaches to treat a wider ...

core