Results 121 to 130 of about 963,191 (312)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals [PDF]

, 2012
Non
Rocco, P, Jan Wernerman, Preiser, Jean-Charles, Mancebo, J, Timsit, JF, Salvatore M. Maggiore, Mancebo, Jordi, Maggiore, Salvatore M, Mebazaa, A, Jordi Mancebo, Curtis, JR, Bonten, M, Marc Bonten, Conti, G, Macrae, D, Antonelli, M, Curtis, Randall J.R., Maggiore, Salvatore Maurizio, Rocco, Patricia, Chastre, J, Maggiore, Salvatore M., Preiser, JC, Giorgio Conti, Chastre, Jean, Giuseppe Citerio, Citerio, Giuseppe, Goran Hedenstierna, Mebazaa, Alexandre, Maggiore, SM, Antonelli, Massimo, Joannidis, Michael, Timsit, Jean François, Massimo Antonelli, Jean Chastre, Wernerman, J, Maurizio Cecconi, J. Randall Curtis, Hedenstierna, Goran, Timsit, Jean-François, Joannidis, M, Haibo Zhang, Citerio, G, Jean-François Timsit, Jean-Charles Preiser, MacRae, Duncan, Alexandre Mebazaa, Michael Joannidis, Preiser, Jean Charles, Hedenstierna, Göran,, Conti, Giorgio, Cecconi, M, Hedenstierna, G, Wernerman, Jan, Bonten, Marc, Cecconi, Maurizio, Patricia Rocco, Curtis, J.Randall, Universitat Autònoma de Barcelona, Zhang, H, Zhang, Haibo, Duncan Macrae, Curtis, J Randall   +61 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Prognosis of Patients Transferred From Intensive Care Units to Departments of Chest Diseases and the Factors Affecting Their Prognosis

, 2011
Aim: One-third of deaths due to a critical disease occur after patients are transferred from intensive care units to hospital departments. Some of the deaths occur in patients who are considered not to need further intensive care treatment or that they ...
Serdar Kalemci, Can Sevinc, Hulya Ellidokuz, ELLİDOKUZ, HÜLYA, Kalemci, Serdar, SEVİNÇ, CAN   +5 more
core   +1 more source

Protocol for the ADDITION-Plus study : a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care. [PDF]

, 2011
Background The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed.
Wendy Hardeman, Brage, S, Wareham, Nicholas J, Fanshawe, Thomas R., Williams, Kate M, Williams, KM, Nicholas J Wareham, Grant Julie, Fanshawe Tom, Whittle Fiona, Hobbis, Imogen, Griffin, SJ, Grant, J, Kate M Williams, Grant, Julie, Fanshawe, Thomas, Hobbis, I, Simmons, Rebecca K., Fiona Whittle, Griffin, Simon J, Whittle, F, Westgate Kate, Kinmonth Ann, Wareham Nicholas J, Simon J Griffin, Simmons, Rebecca K, Boase, Sue, Westgate, Kate, Brage Soren, Imogen Hobbis, Sutton, Stephen, Wareham, Nicholas J., Fanshawe, T, Julie Grant, Stephen Sutton, null null, Rebecca K Simmons, Griffin, Simon J., Prevost, A. Toby, Kinmonth, AL, Kate Westgate, Boase Sue, Whittle, Fiona, Prevost A Toby, Williams, Kate M., Williams Kate M, Prevost, A. Toby; id_orcid, Kinmonth, Ann Louise, Sutton Stephen, Westgate, K, Hardeman, Wendy, Boase, S, Fanshawe, Tom, Tom Fanshawe, Soren Brage, Prevost, A Toby, Ann Louise Kinmonth, Hobbis Imogen, Simmons Rebecca K, team, ADDITION-Plus study, A Toby Prevost, Simmons, RK, Sutton, S, Brage, Soren, Griffin Simon J, Sue Boase, Hardeman, W, Wareham, NJ, Prevost, AT, Hardeman Wendy   +69 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Predicting the Need for Intensive Care Unit Treatment After Successful Transcatheter Edge-to-Edge Mitral Valve Repair

Background/Objectives: Transcatheter edge-to-edge mitral valve repair (M-TEER) has emerged as an efficacious treatment modality among patients at high perioperative risk. Given the steady increase in procedures and the limited capacity for intensive care,
Fares Kano, Nikolaos Patsalis, Dimitar Divchev, Carlo-Federico Fichera, Dieter Fischer, Felix Ausbuettel, Christin Fichera   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Treatment of periodontitis and endothelial function

, 2007
Background: Systemic inflammation may impair vascular function, and epidemiologic data suggest a possible link between periodontitis and cardiovascular disease.
Deanfield, John, Nibali, Luigi, Suvan, Jean, Vallance, Patrick, Storry, Clare, Nibali, L., Donald, Ann, D'Aiuto, F., Storry, C., Parkar, Mohamed, Vallance, P., Hingorani, A.D., Tonetti, Maurizio S., Parkar, M., Deanfield, J., Hingorani, Aroon D., Suvan, J., Donald, A., D'Aiuto, Francesco, Tonetti, M.S.   +19 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source