Results 61 to 70 of about 548,323 (297)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Qu’appelle-t-on agir? [PDF]

open access: yesMeta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2011
Review of: Jakub Čapek, Action et situation. Le sens du possible entre phénoménologie et herméneutique, Hildesheim, Zürich, New York : Georg Olms Verlag, 2010, 252 p.
Cristian Moisuc
doaj  

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Les particularités de la communication didactique dans la classe de langue [PDF]

open access: yesAnadiss, 2012
Didactic communication is a particular type of communication based on the collaboration between a teacher and students, both parts aiming at realizing the specific educational goals required by the curriculum.
Viorica CONDRAT
doaj  

The Performative Aspects of Metaphor: The Metaphorization of Silence between Intentionality and Conventionality

open access: yesEidos. A Journal for Philosophy of Culture, 2019
Metaphor, as is known, has been considered an expression of the creative approach of a subject to language and thinking. Metaphor enables the subject of cognition and action to establish meaning – the subject exercises semiosis not only by referring to ...
Maria Gołębiewska
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Zasada podwójnego skutku i zasada moralnej symetrii a kwestia legalizacji eutanazji [Principles of Double Effect and Moral Symmetry and Legalization of Euthanasia] [PDF]

open access: yesAnaliza i Egzystencja, 2013
In this essay I scrutinize importance of Principles of Double Effect and MoralSymmetry in regard to the question of moral acceptance of euthanasia legalization.My conclusion is that although there is no substantially moral difference betweenpassive and ...
Wacław Janikowski
doaj  

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

IMPOSSIBLE INTENTIONS

open access: yesAmerican Philosophical Quarterly, 2020
Abstract Philosophers are divided on whether it is possible to intend believed-impossible outcomes. Several thought experiments in the action theory literature suggest that this is conceptually possible, though they have not been tested in ordinary social cognition.
Wesley Buckwalter   +2 more
openaire   +2 more sources

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