Results 101 to 110 of about 101,554 (258)

Determinants of User Intention toward IT Instruction: an Examination of Internal and External Factors

Knowledge Management & E-Learning: An International Journal, 2009
This paper discusses the internal and external factors that affect user intention to apply IT instruction. The internal factors were examined from the standpoint of user attitudes toward IT instruction, which included computer knowledge, perceived ...
Show-Hui S. Huang, Wen-Kai K. Hsu
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PROPENSÃO À ADOÇÃO DE NOVAS TECNOLOGIAS POR PROFESSORES NA PRODUÇÃO DE CONTEÚDOS EDUCACIONAIS: UM ESTUDO COM BASE NA TEORIA DA DIFUSÃO DE INOVAÇÕES

Revista Gestão Universitária na América Latina, 2013
The aim is to understand the differing levels of new technology of information and communication adoption amongst lectures who took part of a project of applying new technologies to teaching and learning practices.
Telma Regina da Costa Guimarães Barbosa, Maria de Lourdes de Carvalho, Silvane Guimarães Silva Gomes, João Batista Mota   +3 more
doaj  

Factors influencing Generation Z’s intention to apply for jobs

Annals of Human Resource Management Research
Purpose: The objective of this research is to examine factors that attract labor, such as worker status, working conditions and environment, and career development opportunities, and to analyze their impact on Generation Z's intentions in deciding to apply for a job.
Albert Kurniawan Purnomo, Muhammad Chairil Barkah, Asslam Assa Adat, Hanifah Safitri   +3 more
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Consumer Perceptions of Private Label Brands in Pakistan

The Lahore Journal of Business, 2017
As the world market share of private label brands (PLBs) increases, so does the importance of and need for research in this field. Given the growing presence of PLBs in Pakistan, this study aims to examine the effects of service quality on PLB image ...
Sana Azar, Samra Chaudary, Ansa Mehmood
doaj