Results 251 to 260 of about 2,286,633 (312)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Determinants of Nurses' Continuance Intention to Use Mobile Health Apps in Clinical Nursing Practice: Structural Equation Modeling to Extend the Expectation-Confirmation Model. [PDF]

JMIR Nurs
Mirabootalebi N, Holl F, Meidani Z, Rangraz Jeddi F, Tagharrobi Z, Akbari H, Swoboda W.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Using a Technology Acceptance Model to Explore the Intention to Use Digital Health Technologies Among People With Disabilities: Cross-Sectional Survey Study. [PDF]

J Med Internet Res
Kim JH, Kim J, Youn BY.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Determinants of chronic disease patients' intention to use Internet diagnosis and treatment services: based on the UTAUT2 model. [PDF]

Front Digit Health
Zhao J, Li B, Sun J, Zeng X, Zheng J.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Understanding pregnant women's intention to use mobile health apps and its determinants: applying the UTAUT model in a mixed-methods study. [PDF]

BMC Prim Care
Asadollahi F, Zagami SE, Roudsari RL.
europepmc   +1 more source

Predictors of pregnant and breastfeeding women's intention to use traditional Chinese medicine: a cross-sectional study from China. [PDF]

BMC Complement Med Ther
Li Z, Li J, Lan Y, Ma L, Xuan L.
europepmc   +1 more source

Intention to use long-acting and permanent contraceptive methods and its predictors among family planning users in Ethiopia: Systematic review and meta-analysis. [PDF]

J Public Health Res
Ferede YA, Zeleke AM, Tassew WC.
europepmc   +1 more source