Results 111 to 120 of about 144,079 (272)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Frontiers in Psychology, 2013 A popular model for the representation of time in the brain posits the existence of a single, central clock. In that framework, temporal distortions in perception are explained by contracting or expanding time over a given interval.
Brent D Parsons +3 more
doaj +1 more source
Towards a Principled Representation of Discourse Plans [PDF]
, 1994 We argue that discourse plans must capture the intended causal and decompositional relations between communicative actions. We present a planning algorithm, DPOCL, that builds plan structures that properly capture these relations, and show how these ...
Moore, Johanna D. +2 more
core +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Delayed visual feedback of one’s own action promotes sense of control for auditory events
Frontiers in Integrative Neuroscience, 2015 Sense of control refers to one’s feelings to control environmental events through one’s own action. A prevailing view is that the sense of control is strong (or is not diminished) when predicted sensory signals, which are generated in motor control ...
Takahiro eKawabe
doaj +1 more source
Ontology and Reason Giving in Law [PDF]
, 2016 John Gardner has noted that legal positivism is more a theory of legal validity than it is a theory about law ’ s nature. 1 This is true in that one can be a legal positivist and hold a variety of different theories about law ’ s nature, but not to the
Ehrenberg, Kenneth M.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Social transmission of experience of agency: an experimental study
Frontiers in Psychology, 2016 The sense of controlling one’s own actions is fundamental to normal human mental function, and also underlies concepts of social responsibility for action.
Nima Khalighinejad +3 more
doaj +1 more source