Results 101 to 110 of about 367,581 (336)

Free Will: Real or Illusion - A Debate [PDF]

open access: yes, 2020
Debate on free will with Christian List, Gregg Caruso, and Cory Clark.
Caruso, Gregg D.   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The Pertinence of Incontinence

open access: yesPrincipia: An International Journal of Epistemology, 2005
In this paper I suggest a reconstruction of the traditional concepts of con-tinent and incontinent action. This reconstruction proceeds along the lines of a standpoint of bounded rationality.
António Zilhão
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

How people explain their own and others’ behavior: A theory of lay causal explanations

open access: yesFrontiers in Psychology, 2015
A theoretical model is proposed that speci¬fies lay causal theo¬ries of behavior; and supporting experimental evidence is presented. The model’s basic assumption is that diffe¬rent types of behavior trigger different hypotheses concerning the types of ...
Gisela eBöhm, Hans-Rüdiger ePfister
doaj   +1 more source

Review of The Stuff of Thought by Steven Pinker (2008) (review revised 2019) [PDF]

open access: yes, 2019
I start with some famous comments by the philosopher (psychologist) Ludwig Wittgenstein because Pinker shares with most people (due to the default settings of our evolved innate psychology) certain prejudices about the functioning of the mind, and ...
Starks, Michael
core  

Negation, expressivism, and intentionality [PDF]

open access: yes, 2020
Many think that expressivists have a special problem with negation. I disagree. For if there is a problem with negation, I argue, it is a problem shared by those who accept some plausible claims about the nature of intentionality.
Carballo, Alejandro Pérez
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

A BRIEF EVALUATION OF HIJĀʾ (SATIRE) DEVELOPMENT IN ANCIENT ARABIC POETRY

open access: yesقضايا لغوية
This study was aimed to show that the purpose of Hijāʾ (invective, lampoon, satire poetry) was directly linked to war. invective poetry of War is one of the main types or genres of Classical Arabic poetry, but the studies did not explain the reason for
Layla DARWISH
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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